What is Paget’s Disease

pagets DiseasesPaget’s disease of bone interferes with the body’s ability to recycling process, in which new bone tissue slowly replaces old bone tissue. Over time, the disease can affect bones, and they can become fragile, and misshapen. Paget’s disease of bone most commonly occurs in the pelvis, spine, skull, and legs.

The risk of Paget’s disease of bone grows with age. Your risk also increases if any family mentors have this disorder. There are complications with Paget’s diseases such as broken bones, having pinched nerves in the spine as well as legs and spine.

Bisphosphonates- medications also used to strengthen bones weakened by osteoporosis- are the primary treatment. IN extreme cases surgery may be needed

Symptoms of Paget’s Disease.
Most people who suffer from Paget’s disease of none have no symptoms, When symptoms occur, the most common issue is bone pain.
Since the disease causes your body to produce new bone faster than normal, the rapid remodeling allows bone that’s softer and weaker than normal bone, which can lead to bone pain, deformities, and fractures.

The disease might change only one or two sections of your body or may be widespread. Your signs and symptoms, if any will depend on the modified part of your body.

Pelvis – Padget’s disease of bone in the pelvis can create hip pain.
Skull, A growth of bone in the skull, can cause hearing loss of headaches.
Spin. If your spine is affected, nerve roots can become compressed. This caused pain, tingling, and numbness in an arm or leg.

Leg As the bone weakens, they may be- causing you to become bowlegged. Enlarged and misshapen bones you legs can put extra stress on nearby joints which may cause osteopathists in the need or hip.

When Should you see a doctor? You should speak to your doctor if you have
Tingling and weakness
Bone deformities
Pain in your bones and joints.

Causes
The cause of Paget’s disease of bone is unexplained. Researchers suspect a mixture of environmental and hereditary factors contribute to the disease. Various genes appear to be linked to getting the disease.”
Some scientists believe pages disease of bone is related to a viral infection in your bone cells. But this is not full vetted.

Risk Factors
Factors that can raise your risk of Paget’s disease of bone include.
Age People older than 40 are most inclined to develop Paget’s disease of bone.
Gender Men are more commonly affected than women.
National Origin Paget’s disease of bone is more prevalent in England, Scotland central Europe and Greece – as well as countries settled by European. It’s rare in Scandinavia and Asia.
Family History. If you have a close family member who has Paget’s disease of one, you’re more likely to develop the condition.

pagets Diseases2Complications.

In most cases, Paget’s disease of the bone of bone process slowly. The disease can be managed efficiently by nearly all people. Possible complication include:

Features and deformities. Affected bones break more easily. Extra blood vessels in these irregular bones cause them to bleed more during repair surgeries. Leg bones can bowl which can affect you the ability to walk.

Osteoarthritis Misshapen bones can expand the amount of stress on nearby joints which can cause osteoarthritis.
Heart Failure. Extensive Paget’s disease of bone may push your head to work harder to pump blood to the afflicted areas of your body. IN people with pre-existing heart disease, the increased workload can lead to heart failure.

Bone cancer – Bone cancer occurs in less than 1 percent of individuals with Paget’s disease of bone.

Diagnosis
During the physical exam, you doctor will examine areas of your body that are causing you pain. He or she may request X0rays and blood test that can help confirm the diagnosis of Paget disease of bone.

Imaging tests
Bone alterations common to Paget’s disease of bone can be revealed by

X-ray the first indication of Paget’s disease of bone is often abnormalities food on X-rays done for other reason. X-ray images of your bones can reveal areas of bone reabsorption. Enlargement of the bone and deformities that are characteristic of Paget’s disease e of bone, such as bowing of your long bones.

Bone scan. In the bone scan, radioactive material is injected into your body. This material travels to the spots on your bones most affected by gadgets disease of bone, so they light up on the scan images.

Lab tests
Individuals who have Paget’s disease of bone frequently have raised levels of Alkaline phosphatase in their blood; which can be exhibited by a blood test.
Paget;s Disease Treatment
If you don’t have symptoms, you might not need treatment. However, fi the disease is active – indicating by an elevated alkaline phosphatase level ad is affecting high-risk sections in your body, such as your skull or spine, your physician might prescribe treatment to prevent complications, even if you do not have symptoms.

Medicationspagets Diseases1

Osteoporosis drugs (bisphosphonates) are the most common treatment for Paget’s disease of bone. Some bisphosphonates are taken by mouth, while other medications may be given by injection. Oral bisphosphonates are normally well tolerated, but may array your gastrointestinal tract. Example include
Pamidronate (Aredia)
Risedronate (Actonel)
Ibandronate (Boniva)
Zoledronic acid (Zometa Reclast)
Alendronate (Fosamax)

Rarely, bisphosphonate therapy has been lined to severe muscle, joint or bone pain, which might not fix when the medication is discontinued. Bisphonates also can raise the risk of a rare condition in which a segment of jawbone dies and declines ( osteonecrosis of the jawbone), usually associated with dental diseases or a tooth extraction.
If you can not tolertate bisphosphonates, your doctor might prescribe calcitonin (Miacalcin), a naturally occurring hormone involved in calcium control and bone metabolism Calcitonin is a drug that you administer to yourself by injection or nasal spray. Side effects may include nausea, facial flushing at the injection site.

Surgery

In rare cases, surgery might be required to help Features heal
Replace joints damaged by severe arthritis
Realign deformed bones
Reduce pressure on nerves.

Paget’s disease of the bone often triggers the body to produce too many blood vessels sin affected bones, developing the risk of serious blood loss during an operation. If you are scheduled for the survey that involves bone affect by Paget’s disease, your doctor might recommend medications to reduce the activity of the decade which tends to reduce the loss of blood during surgery.

Lifestyle and Home Remedies

Prevent falls Paget’s disease of bone put you at risk of bone fractures your doctor for advice on stopping falls. He or she may recommend that you use a cane or walker.
Fall proves your home. Remove slippery floor covers, use nonskid mats in your bathtub or shower., tuck away cords, and fit handrails on stairways and grab bars in your bathroom.

Eat well. Be sure your diet includes adequate levels of calcium and vitamin D, which helps bones absorb calcium. This is particularly important if you are taking a bisphosphonate.

Exercise regularly. Regular exercise is essential for maintaining joint mobility and bone strength. Talk o your doctor before beginning an exercise program to determine the right type intensity and duration of exercise for you.


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