Vitamin B 6

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(Pyridoxine)

Since most foods contain vitamin B6, a nutritional deficiency is rare. A secondary deficiency can be attributed to various causes. Symptoms of peripheral neuropathy, a pellagraähnliches syndrome, anemia and seizures that do not disappear especially in young children are when they are treated with anticonvulsants. A restricted metabolism (dependence) is rare; it causes various symptoms such as seizures, mental retardation and anemia. The diagnosis is made clinically; There is no laboratory test that the vitamin B6 status can be determined directly. To eliminate the deficiency, vitamin B6 is administered orally and, if possible, treat the cause.

Vitamin B6 comprises a group of closely related components: pyridoxine, pyridoxal and pyridoxamine. They are metabolized in the body to pyridoxal phosphate, which acts as a coenzyme in important reactions in blood, CNS and skin metabolism. Vitamin B6 plays a significant role in the biosynthesis of heme and nucleic acid and the lipid, carbohydrate and amino acid metabolism (see table: sources, functions and effects of vitamins).

(. See also overview of vitamins) Vitamin B6 comprises a group of closely related components: pyridoxine, pyridoxal and pyridoxamine. They are metabolized in the body to pyridoxal phosphate, which acts as a coenzyme in important reactions in blood, CNS and skin metabolism. Vitamin B6 plays a significant role in the biosynthesis of heme and nucleic acid and the lipid, carbohydrate and amino acid metabolism (see table: sources, functions and effects of vitamins). Vitamin B6 deficiency and dependence Since most foods contain vitamin B6, a nutritional deficiency is rare. A secondary deficiency can be attributed to various causes. Symptoms of peripheral neuropathy, a pellagraähnliches syndrome, anemia and seizures that do not disappear especially in young children are when they are treated with anticonvulsants. A restricted metabolism (dependence) is rare; it causes various symptoms such as seizures, mental retardation and anemia. The diagnosis is made clinically; There is no laboratory test that the vitamin B6 status can be determined directly. To eliminate the deficiency, vitamin B6 is administered orally and, if possible, treat the cause. Etiology created a dietary vitamin B6 deficiency – though rarely – as an intensive processing of foods can reduce their vitamin B6 content strong. Secondary VitaminB6Mangel is most commonly caused by protein malnutrition malabsorption alcoholism taking pyridoxindeaktivierenden drugs (eg. As anticonvulsants, isoniazid, cycloserine, hydralazine, corticosteroids, penicillamine) Excessive loss during hemodialysis Rarely is a secondary defect as a result of increased metabolic demand (z. B. in hyperthyroidism). Rare congenital metabolic disorders affecting the Pyridoxinstoffwechsel.Symptome and complaints vitamin B6 deficiency causes a peripheral neuropathy and a pellagraähnliches syndrome with seborrheic dermatitis, glossitis and Cheilose, adult depression, confusion, EEG abnormalities and seizures may occur. In rare cases, deficiency or dependency affects infants seizures. Especially with young children, seizures with anticonvulsant drugs are difficult to treat. Normocytic, microcytic or sideroblastäre anemia can also be due to lack entwickeln.Diagnose Clinical examination Vitamin B6 deficiency should be considered in every infant with seizures, any patient with seizures that do not improve while taking anticonvulsants, each patient with a deficiency of other B-vitamins, in particular alcoholism and protein-energy malnutrition. The diagnosis of a vitamin B6 deficiency is clinical in general. There is no single accepted laboratory test for the determination of vitamin B6 status; the measurement of pyridoxal phosphate in the serum is the most widespread. Tips and risks if the seizures in infants under Antiepileptikatherapie not suspend the administration of pyridoxine should be given to treat a possible vitamin B6 deficiency. Therapy pyridoxine off of risk factors, if possible in the case of a secondary vitamin B6 deficiency causes such pyridoxindeaktivierende drugs or malabsorption should be eliminated if possible. In general, the lack disappears in adults, once daily 50-100 mg pyridoxine be given orally. Patients taking isoniazid should also po 30-50 mg / day pyridoxine receive. There is a defect due to an increased metabolic demand, Pyridoxingaben are needed in larger amounts than the recommendations for daily intake so provide. For the treatment of most inborn metabolic error pyridoxine can in high doses administered werden.Wichtige points A vitamin B6 deficiency is usually caused by pyridoxindeaktivierende drugs (eg. As isoniazid), protein-energy malnutrition, malabsorption, alcoholism or excessive losses. A deficiency can peripheral neuropathy, dermatitis, glossitis and Cheilosis and cause adult depression, confusion and seizures. The suspicion and the diagnosis is based on clinical findings. The secondary causes should be eliminated or in addition, pyridoxine are added. Vitamin B 6 -Intoxikation Taking pyridoxine in an overdose of> 500 mg / day (eg., For treatment of carpal tunnel syndrome or premenstrual syndrome despite unproven efficacy) causes a peripheral neuropathy with hand-foot syndrome and in this context progressive sensory ataxia and severe impairment of position and vibratory sensation. The touch, temperature and pain sensation are less affected. The motor and central nervous system works smoothly in general. The diagnosis of vitamin B6 intoxication is created clinically. As part of the therapy of vitamin B6 poisoning the intake of vitamin B6 should be discontinued. The recovery is slow and sometimes incomplete.

Health Life Media Team

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