For more information, s. MMR Vaccine ACIP Recommendations (Measles, Mumps and Rubella). Preparations The vaccine against measles, mumps and rubella (MMR) contains live attenuated viruses of measles and mumps, which are produced in chicken embryo cell cultures. It also contains attenuated rubella live virus produced in human diploid lung fibroblasts. The MMR vaccine and the varicella vaccine is a combination vaccine (MMRV vaccine) available. Indications The MMR vaccine is a routine childhood vaccination (see Table: Recommended vaccination schedule for the age of 0-6 years). All adults who were born in 1957 or later should be administered 1 dose of the vaccine, provided that they have one of the following conditions: Documentation of the immunization with one or more doses of MMR laboratory evidence indicative of an immunity to the 3 diseases a contraindication for the the vaccine documented disease diagnosis by a physician is not considered acceptable evidence of immunity to measles, mumps or rubella. A second dose of MMR vaccine is recommended for adults who are likely to be exposed to the following conditions: students at universities and other tertiary educational institutions health workers International travelers Since rubella during pregnancy can have fatal consequences for the fetus (eg. B. miscarriage, multiple birth defects) should all women of childbearing age, regardless of their year of birth, be tested for immunity to rubella. If no evidence exists for immunity, women who are not pregnant should be vaccinated. Pregnant women who have no evidence of immunity should be vaccinated, if the pregnancy is complete and before they are released from the health facility. Persons who have been vaccinated 1963-1967 with the deactivated (killed) measles vaccine or measles vaccine, whose type is unknown should receive 2 doses of the MMR vaccine again. Persons who have been pre-1979, vaccinated with killed mumps vaccine or with a mumps vaccine, whose type is unknown, and for, is the risk to be exposed to mumps, a booster injection with 2 doses of the MMR vaccine should Tobe offered. Contraindications and precautions include the following contraindications: a severe allergic reaction (e.g., anaphylaxis.) After a previous dose or to a vaccine component, including neomycin Known heavy primary or acquired immunodeficiency (e.g., due to leukemia; lymphomas, solid tumors;. tumors affecting the bone marrow or the lymphatic system; AIDS; severe HIV infection; treatment with chemotherapy; or long-term use of immunosuppressants) pregnancy (vaccination is postponed until pregnancy is over) HIV infection is only in severe immunodeficiency a contraindication (stage 3 according to CDC criteria with <15% CD4-cell Immunological categories for children <13 years with HIV infection based on age-specific CD4 + T cell counts and percentages of total Lymphozytenza hl); if the immunodeficiency is not difficult, the risk of wild-type measles disease is higher than the risk of measles infection because of the live vaccine. Women who have been vaccinated should avoid becoming pregnant within ? 28 days after vaccination. The vaccine virus may be able to infect a fetus during early pregnancy. The vaccine does not cause congenital rubella syndrome, but the risk of fetal loss is estimated to ? 3%. The precautions include Moderate or severe acute illness with or without fever (vaccination, if possible, be postponed until the disease is over) Recent (within 11 months) treatment with blood products contain antibodies (specific interval depends on the product) history of thrombocytopenia or thrombocytopenic purpura When a person with Mycobacterium tuberculosis is infected, the MMR and possibly the MMRV vaccine can temporarily suppress the reaction to tuberculin tests. Thus, this test, if necessary, prior to or simultaneously be performed with vaccination. If people have already been vaccinated, the testing should be postponed to 4 to 6 weeks after vaccination. Dosage and administration dose is 0.5 ml and s.c. administered. The MMR vaccine is given to children routinely in two doses: one at the age of 12 to 15 months and one aged 4 to 6 years. Side effects Vaccination leads to a minor or inapparent, noncommunicable infection. Symptoms include a fever> 38 ° C, which is sometimes followed by a rash. CNS reactions are very rare; the vaccine does not cause autism (anti-vaccination movement: MMR vaccine and autism and Professional.heading on page overview of immunization: vaccination safety). Occasionally, the rubella component causes in adults painful joint swelling, usually in women.