A number of connective tissue disease causes inflammation of the middle eye skin. Spondyloarthropathies serology negative spondyloarthropathies (overview of seronegative spondyloarthropathies) are a common cause of anterior uveitis. RA, however, is not associated with isolated uveitis, but may cause scleritis, which may ignite the secondary medium eyes skin. Most commonly, an eye inflammation in ankylosing spondylitis occurs but it may be in reactive arthritis, inflammatory bowel disease (ulcerative colitis and Crohn’s disease), and occur at a psoriatic arthritis. The uveitis is usually one-sided, but recurrence is common and active inflammation can switch between the two eyes. Men are more frequently affected than women. Most patients are regardless of their gender HLA-B27-positive. For the treatment of a topical corticosteroid and a zykloplegisch-mydriatic drug is required. Occasionally periocular corticosteroids are needed. Severe chronic cases may require non-corticosteroid immunosuppressants (eg., Methotrexate, mycophenolate mofetil). Juvenile idiopathic arthritis (JIA, formerly known as juvenile RA) The JIA causes in children typically a chronic bilateral iridocyclitis, especially those of oligoarticular type (juvenile idiopathic arthritis (JIA)). Unlike most forms of anterior uveitis, however, JIA does not cause eye pain, photophobia, and conjunctival injection, but only blurred and miosis, and is therefore often referred to as white iritis. JIA-associated uveitis is more common in girls than in boys. Recurrent attacks of inflammation are best treated with a topical corticosteroid and a zykloplegisch-mydriatic drug. The long-term treatment often requires non-corticosteroid immunosuppressants (for. Example, methotrexate, mycophenolate mofetil). Sarcoidosis The sarcoidosis (sarcoidosis) caused 10-20% of Uveitisfälle and about 25% of patients with sarcoidosis develop uveitis. Sarcoidosis uveitis is more common in blacks and the elderly. It can occur practically all the symptoms and discomfort of anterior uveitis, intermedia, posterior, or panuveitis. Suspect findings include Bindehautgranulome, large Keratinausscheidungen on the corneal endothelium (known as granulomatous or greasy precipitates) Irisgranulome and retinal vasculitis. The biopsy of the suspicious injuries, which is the surest diagnosis is performed usually on the conjunctiva; on the intraocular tissues it is rarely performed because of the high risk during the procedure. The treatment is usually with topical, periocular, intraocular or systemic corticosteroids, or a combination, together with a zykloplegisch-mydriatic drug. Patients with moderate to severe inflammation may require a non-kortikosteroidales immunosuppressant (eg., Methotrexate, mycophenolate mofetil, azathioprine). Sarcoidosis (Bindehautgranulom) Image courtesy of Stephen C. Pollock about the Online Journal of Ophthalmology (www.onjoph.com). var model = {thumbnailUrl: ‘/-/media/manual/professional/images/sarcoidosis_conjunctival_high_de.jpg?la=de&thn=0&mw=350’ imageUrl: ‘/-/media/manual/professional/images/sarcoidosis_conjunctival_high_de.jpg?la = en & thn = 0 ‘, title:’ sarcoidosis (Bindehautgranulom) ‘description:’ u003Ca id = “v37894326 ” class = “”anchor “” u003e u003c / a u003e u003cdiv class = “”para “” u003e u003cp u003eAuf this picture you can see a sarcoidosis granuloma bulbar conjunctiva of u003c / p u003e u003c / div u003e ‘credits’. image courtesy of Stephen C. Pollock about the online Journal of Ophthalmology (www.onjoph.com) ‘hideCredits: false