Undersatnd Celiac Disease

(Glutenenteropathie)

Celiac disease is an immune-mediated disease in genetically susceptible individuals. It is caused by an intolerance to gluten that causes intestinal mucosal inflammation, villous atrophy and malabsorption. The symptoms is usually from diarrhea and abdominal discomfort. The diagnosis is made by using a small bowel biopsy, the characteristic, but not specific pathological changes in the sense of villous atrophy shows that is regress by a strict gluten-free diet.

(See also the ACG Clinical Guidelines. Diagnosis and Management of Celiac Disease)

Celiac disease is an immune-mediated disease in genetically susceptible individuals. It is caused by an intolerance to gluten that causes intestinal mucosal inflammation, villous atrophy and malabsorption. The symptoms is usually from diarrhea and abdominal discomfort. The diagnosis is made by using a small bowel biopsy, the characteristic, but not specific pathological changes in the sense of villous atrophy shows that is regress by a strict gluten-free diet. (See also the ACG Clinical Guidelines. Diagnosis and Management of Celiac Disease) Celiac disease is a Malabsorptionsstörung. Etiology Celiac disease is a hereditary disease, which is caused by an increased sensitivity to the gliadin fraction of gluten, a wheat protein. Similar proteins are found in rye and barley. In genetically susceptible individuals gluten-specific T cells are activated when they are presented by the gluten peptide epitopes. The inflammatory response resulting in the characteristic villus atrophy of the small intestine. Epidemiology celiac disease mainly affects people of northern European descent. Prevalence estimates based on serological testing among blood donors (sometimes by biopsy confirmed), show that the disorder in Europe, especially in Ireland and Italy, about 1 out of 150 people there and maybe 1 out of 250 people in some parts of the US , Current estimates of the prevalence in some regions are at 1: 100. The disease manifests itself at about 10-20% of children ( “1st-degree relatives”) affected. The ratio female to male is 2: 1. In general, the disease occurs in childhood, but also later. Patients who have other diseases such as lymphatic colitis, Down syndrome, type diabetes mellitus, and autoimmune (Hashimoto) thyroiditis have to develop celiac disease risk. Symptoms and signs The clinical presentation varies; There is not a typical appearance. Some patients are asymptomatic or have only sign of a nutritional deficiency. Others suffer from significant gastrointestinal symptoms. Celiac disease can (mostly cereals) manifest in the diet in young children or in youth by ingestion of cereal products. The children no longer grow, they are apathetic, anorexic, pale, generally hypotonic with abdominal distention and muscle wasting. The chair is soft, voluminous, kleiefarben and malodorous. In older children, anemia or growth disorder may be present. In adults, fatigue, weakness and anorexia are the most common symptoms. A small, intermittent forming diarrhea may be initial symptom sometimes steatorrhea varies in severity between low and heavy (7-50 g fat / day). Many patients suffer from weight loss, but usually not so severe that they are underweight. Common Anemia, inflammation of the tongue and mouth and mouth ulcers are seen in these patients. Often, a vitamin D or -Kalziummangel manifested (z. B. as osteomalacia, osteopenia, osteoporosis). Both men and women exhibit reduced fertility; in women may menstruation does not occur. In approximately 10% of patients dermatitis herpetiformis occurs accompanied by an intense itching papulovesikulärer rash, symmetrically distributed on the extensor surfaces of the forearm, on knees, buttocks, shoulders and head. This rash can be caused by a gluten-containing food. Dermatitis herpetiformis © Springer Science + Business Media var model = {thumbnailUrl: ‘/-/media/manual/professional/images/499-dermatitis-herpetiformis-slide-10-spriinger-high_de.jpg?la=de&thn=0&mw=350 ‘imageUrl:’ /-/media/manual/professional/images/499-dermatitis-herpetiformis-slide-10-spriinger-high_de.jpg?la=de&thn=0 ‘, title:’ dermatitis herpetiformis ‘description’ u003Ca id = “v37892559 ” class = “”anchor “” u003e u003c / a u003e u003cdiv class = “”para “” u003e u003cp u003eDiese figure shows dermatitis herpetiformis (with a symmetrical itchy papulovesikulärem rash ) on the extensor surface of the elbow u003c / p u003e u003c / div u003e. ‘credits’ © Springer Science + Business Media’

Health Life Media Team

Leave a Reply