Transient hypogammaglobulinemia in children is a transient decrease in serum IgGs and sometimes the IgAs and other Ig isotypes to a level below the age-based normal values.

(See also Overview of immune deficiency disorders, and approach to the patient with an immunodeficiency disorder.)

Transient hypogammaglobulinemia in children is a transient decrease in serum IgGs and sometimes the IgAs and other Ig isotypes to a level below the age-based normal values. (See also Overview of immune deficiency disorders, and approach to the patient with an immunodeficiency disorder.) Transient hypogammaglobulinaemia in childhood is a primary immune deficiency disease, are among the humoral immunity deficiencies. In this disease, the IgG levels remain even after the physiological decline in maternal IgG, around the age of 3 to 6 months, low. The cause and the pattern of inheritance is unknown. The condition rarely causes severe infection and it is therefore not thought of a pronounced immune deficiency. The condition is usually asymptomatic. However, some patients develop sinopulmonary or gastrointestinal infection, candidiasis and / or meningitis. The diagnosis of transient hypogammaglobulinemia based on a low serum Ig levels (at least 2 standard deviations below the mean value for the respective age group) and tests show that antibody production in response to vaccine antigens (e.g., as tetanus, diphtheria) is normal. Thus, this condition can be distinguished from permanent forms of hypogammaglobulinemia, are in specific antibodies against vaccine antigens are not produced. Patients with recurrent infections can be treated temporarily with prophylactic antibiotics. Usually immunoglobulin is required. This condition may persist for months to a few years, but heals normally.

Health Life Media Team

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