Tolerance is a reduction in drug effect by repeated taking the drug. Resistance is the ability of microorganisms or tumor cells to resist the originally destructive effects of a drug.

Examples of drugs (drugs) that lead to tolerance, alcohol and opioids. A responsible for the development of tolerance mechanism is an increased metabolism, for example by induction of liver enzymes such as cytochrome P-450 enzymes (drug metabolism). Other possible mechanisms have a reduced binding affinity between drug and receptor, and a decrease in the number of receptors. The authorities responsible for drug tolerance mechanisms are not always known.

Tolerance is a reduction in drug effect by repeated taking the drug. Resistance is the ability of microorganisms or tumor cells to resist the originally destructive effects of a drug. Examples of drugs (drugs) that lead to tolerance, alcohol and opioids. A responsible for the development of tolerance mechanism is an increased metabolism, for example by induction of liver enzymes such as cytochrome P-450 enzymes (drug metabolism). Other possible mechanisms have a reduced binding affinity between drug and receptor, and a decrease in the number of receptors. The authorities responsible for drug tolerance mechanisms are not always known. Tolerance is not the same as addiction. Dependence is characterized by the desire to use a drug (psychological dependence – Overview of substance-dependent diseases: classification of substance-dependent diseases) and / or by unpleasant physical symptoms, so-called withdrawal symptoms that occur after the drug application (physical dependence – Substance-Induced Disorders: Withdrawal). Microorganisms are resistant if they are no longer killed by previously effective antimicrobial drugs or inhibited. The development of resistance begins with a genetic alteration based on a mutation or gene transfer. Since the previously effective antimicrobial drugs preferably effective against non-resistant organisms, the number of resistant organisms increases (overview of antibacterial substances: antibiotic resistance). Similarly, tumors can become resistant if a mutation to an insensitivity to a drug leads against cancer. If the drug is used repeatedly, the non-resistant tumor cells are then mainly killed. So have as many patients with chronic myelogenous leukemia caused by mutations T315I gene of resistance to the tyrosine kinase inhibitor imatinib.

Health Life Media Team

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