As long as the disease of splenomegaly underlying platelet production does not affect (eg. As in myelofibrosis), platelet counts usually stay> 30,000 / ul. Sequestered platelets are released under stress from the spleen. Therefore rarely causes thrombocytopenia, which is solely due to the sequestration in the spleen, bleeding. Splenectomy leads in patients with normal hepatic function to normalization of platelet counts, but is not indicated as long as no severe thrombocytopenia occurs by concomitant bone marrow failure.

In various diseases that lead to splenomegaly, it may consequently lead to an increased sequestration of platelets in the spleen. While the thrombocytopenia (and thus to a decreased platelet production) result in advanced liver cirrhosis mainly to a reduced Thrombopoetinbildung in the liver, the platelets are sequestered in other forms of Stauungsmilz. As long as the disease of splenomegaly underlying platelet production does not affect (eg. As in myelofibrosis), platelet counts usually stay> 30,000 / ul. Sequestered platelets are released under stress from the spleen. Therefore rarely causes thrombocytopenia, which is solely due to the sequestration in the spleen, bleeding. Splenectomy leads in patients with normal hepatic function to normalization of platelet counts, but is not indicated as long as no severe thrombocytopenia occurs by concomitant bone marrow failure.

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