In the white pulp, the formation and maturation of T and B cells takes place. The B-cells in the spleen form protective humoral antibodies. In various autoimmune diseases such. B. in the immune thrombocytopenia (ITP) or Coombs positive anemia immunhämolytischen are synthesized unwanted autoantibodies and released into the peripheral blood.

The spleen is in terms of their structure and function of two organs. The white pulp is composed of periarterial lymphatic sheaths and germinal centers and has an immunological function. The red pulp consists of macrophages and granulocytes, lining the vascular spaces (marrow spaces and sinusoids); their function is phagocytosis. In the white pulp, the formation and maturation of T and B cells takes place. The B-cells in the spleen form protective humoral antibodies. In various autoimmune diseases such. B. in the immune thrombocytopenia (ITP) or Coombs positive anemia immunhämolytischen are synthesized unwanted autoantibodies and released into the peripheral blood. In the red pulp are loaded with antibodies bacteria, aging or defective erythrocytes and antibody-loaded blood cells, such as occur for example at Immunzytopenien (z. B. idiopathic thrombocytopenic purpura, immune hemolytic Coombs positive anemia, various neutropenia), phagocytosed. In addition, the red pulp as a storage reservoir for blood components, particularly for leukocytes and platelets. During the filtration of red blood cells from the spleen inclusion such. B. Heinz bodies (precipitates of insoluble globin), Howell-Jolly body (nuclear fragments) and the entire cell nucleus. Therefore can be detected after a splenectomy or a functional hyposplenism erythrocytes with these inclusions in the peripheral blood. A blood formation in the red pulp normally occurs only during the fetal period. Thereafter, they may occur (due to fibrosis or tumors, for example.) In bone marrow damage, whereby hematopoietic stem cells enter the circulation and adult (postfetale) spleen repopulate (myelofibrosis, primary myelofibrosis, myelodysplastic syndromes, myelodysplastic syndrome).

Health Life Media Team

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