What is Zap-70 Deficiency?

September 3, 2018

The ZAP-70 (zeta-associated protein 70) deficiency is characterized by an impaired T-cell activation, which is caused by a malfunction of signal transduction. ZAP-70 deficiency is a primary immunodeficiency disease which includes cellular immune deficiencies. Inheritance occurs as an autosomal recessive. The ZAP-70 protein plays an essential role in T-cell signaling and T cell selection in the thymus. A ZAP-70 deficiency leads to defects in T cell activation. Patients with ZAP-70…