Microscopic Polyangiitis (Mpa)

Microscopic polyangiitis is a systemic necrotizing vasculitis without immunoglobulin deposition (pauci-immune), which mainly affects small vessels. It can begin as pulmonary renal syndrome with rapidly progressive glomerulonephritis and alveolar hemorrhage, but the patterns of disease depends on the affected organs. Diagnosis is based on clinical findings and is sometimes confirmed by a biopsy. The treatment depends on the severity of the disease, is the administration of corticosteroids and immunosuppressants. Microscopic…

September 3, 2018
Read More >>

Goodpasture’S Syndrome

(Goodpasture’s syndrome, anti-GBM antibody disease) Goodpasture’s syndrome, a subtype of the pulmorenales syndrome is an autoimmune disease with alveolar hemorrhage and glomerulonephritis which is caused by circulating anti-GBM antibody. Most commonly, a Goodpasture’s syndrome develops in genetically predisposed smokers, but exposure to hydrocarbons and respiratory viral infections are other possible triggers. The symptoms is to dyspnea, coughing, fatigue, hemoptysis, and hematuria. A Goodpasture’s syndrome is suspected in patients with hemoptysis…

September 3, 2018
Read More >>

Diffuse Alveolar Hemorrhage

The diffuse alveolar hemorrhage is a persistent or recurrent pulmonary hemorrhage. There are numerous causes, but autoimmune diseases are most common. Most patients show dyspnea, cough, hemoptysis and new alveolar infiltrates on chest image. Diagnostic tests are based on the suspected cause. Treatment is with immunosuppressive drugs in patients with autoimmune causes and respiratory support if necessary. The diffuse alveolar hemorrhage is not a specific disease but a syndrome suggesting…

September 3, 2018
Read More >>