Cachexia In Cancer Patients

Cachexia is not primarily due to anorexia or decreased caloric intake. Rather, the cause of this complex metabolic action in an increased tissue catabolism. Protein synthesis is reduced and increases the degradation. The cachexia is promoted by various cytokines, v. a. Tumor necrosis factor ?, IL-1b and which are produced by tumor and host tissue cells in IL-6. In addition, the ATP-ubiquitin-protease metabolism plays a role. Cachexia refers to the…

September 3, 2018