Antibiotics In Newborns

The absence of or the lack of certain enzymes in neonates causes some antibiotics (chloramphenicol) in a prolonged half-life and increases the risk of toxicity. Changes in the glomerular filtration rate and renal tubular secretion during the first month of life make with other drugs that are renally excreted, a dosage adjustment is necessary (penicillin, aminoglycosides, vancomycin). In newborns, the Extrazellullärraum accounts for 45% of total body weight and requires…