(Renal glycosuria)

Renal glucosuria is glucose in the urine without glycemia. It results from a either acquired or hereditary isolated disorder of glucose transport or occurs in conjunction with other renal Tubulusstörungen.

Renal glucosuria is the excretion of glucose in the urine of normal plasma glucose levels.

Renal glucosuria is glucose in the urine without glycemia. It results from a either acquired or hereditary isolated disorder of glucose transport or occurs in conjunction with other renal Tubulusstörungen. Renal glucosuria is the excretion of glucose in the urine of normal plasma glucose levels. Renal glycosuria can be hereditary. This form is usually based on a reduction in glucose transport maximum (maximum Rückresorptionsrate for glucose) and consequently leads to glucose loss in the urine. The hereditary disorder is usually on incomplete recessive way (heterozygotes simple glucosuria have) transferred. Renal glucosuria may occur without other abnormalities of renal function, or as part of a generalized failure of the proximal tubular function (Fanconi syndrome). It can also occur in connection with various systemic disorders, including Cystinosis, Wilson’s disease, hereditary tyrosinemia and okulozerebrorenale syndrome (Lowe syndrome). Symptoms Renal glucosuria runs without symptoms and does not lead to serious sequelae. However, if there is an associated generalized defect in proximal tubular function, Signs and Symptoms may occur as hypophosphatemic rickets, volume loss, short stature, hypotonia and eye findings with cataracts or glaucoma (okulozerebrorenales syndrome) or Kayser-Fleischer rings (Wilson’s disease). In such findings should be considered in other transport disruptions than the glucosuria. Diagnostic urinalysis 24-hour urine collection, the disorder is usually first noticed during a routine urine test. Diagnosis is based on a finding of glucose in the 24-hour urine collection (if a diet containing 50% carbohydrates) in the absence of hyperglycemia (serum glucose <140 mg / dl). To ensure that this is the excreted sugar is glucose, and a pentosuria, fructosuria, Sucrosurie, Maltosurie, galactosuria and lactosuria rule out the glucose oxidase method should be applied to all laboratory measurements. Some experts call a normal result of an oral glucose tolerance test for diagnosis. Therapy is required no treatment. The isolated renal glucosuria is benign, treatment is not necessary.

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