The reactive thrombocytosis is an elevated platelet count (> 450,000 / ul), which develops secondary to another disease.
include causes of thrombocytosis
The reactive thrombocytosis is an elevated platelet count (> 450,000 / ul), which develops secondary to another disease. A cause of thrombocytosis include chronic inflammatory diseases (eg., Rheumatoid arthritis, inflammatory bowel disease, tuberculosis, sarcoidosis, granulomatosis with polyangiitis [Wegener’s granulomatosis]) Acute infection bleeding iron deficiency hemolysis Malignant Tumor Diseases (particularly Hodgkin’s lymphoma, non-Hodgkin’s lymphoma ) splenectomy myeloproliferative and hematological diseases (eg. as polycythemia, chronic myeloid leukemia, sideroblastic, myelodysplasia [5q-syndrome, RARS-T]) there are also congenital familial thrombocytosis such as those for mutations of the Thrombopoietin- and thrombopoietin receptor gene based. For thrombocytosis, which is secondary to another disease, Essential Thrombocythemia. Platelet function is normal in general. Unlike the essential thrombocythemia thrombocytosis does not lead to an increased risk of thrombosis or bleeding complications, unless there are severe arterial disease or prolonged immobilization. In secondary thrombocytosis, the platelet count is usually <1,000,000 / ul. The reason for this can usually on the basis of medical history and physical examination to be clarified (by confirmatory tests if necessary). Blood counts and peripheral blood smears should give an indication of iron deficiency or hemolysis. When a cause of secondary thrombocytosis is not obvious, patients should be evaluated for a myeloproliferative disease. Such an investigation can cytogenetic studies, including Philadelphia chromosome or BCR-ABL assay, and possibly a bone marrow examination, especially in patients with anemia, macrocytosis, leukopenia and / or hepatosplenomegaly include. The treatment of the underlying disease usually leads to normalization of platelet counts.