The PFAPA syndrome (periodic fever with aphthous ulcers, stomatitis, pharyngitis and lymphadenitis) is a syndrome with periodic bouts of fever. It is typically between the ages of 2 and 5 years. The fevers adhere to 3-6 days, accompanied by pharyngitis, aphthous ulcers, and adenopathy. Etiology and pathophysiology is unclear.

The PFAPA syndrome is a relatively common periodic fever in children. Although the genetic causes have not been precisely defined, this syndrome is usually ranked among the hereditary fever syndromes. It usually starts in early childhood (aged between 2 and 5 years) and tends to be more common in boys.

The PFAPA syndrome (periodic fever with aphthous ulcers, stomatitis, pharyngitis and lymphadenitis) is a syndrome with periodic bouts of fever. It is typically between the ages of 2 and 5 years. The fevers adhere to 3-6 days, accompanied by pharyngitis, aphthous ulcers, and adenopathy. Etiology and pathophysiology is unclear. The PFAPA syndrome is a relatively common periodic fever in children. Although the genetic causes have not been precisely defined, this syndrome is usually ranked among the hereditary fever syndromes. It usually starts in early childhood (aged between 2 and 5 years) and tends to be more common in boys. Fever episodes last for 3-6 days and are repeated approximately every 28 days. The syndrome causes fatigue, chills, and sometimes abdominal pain and headache as well as fever, pharyngitis, aphthous ulcers and lymphadenopathy. Patients are healthy between episodes, and growth is normal. Diagnosis Diagnosis is based on clinical findings, which include the following: ? 3 episodes of fever, lasts up to 5 days and occurs at regular intervals pharyngitis accompanied by adenopathy or aphthous Good health between episodes and normal growth acute phase reactants ( z. B. C-reactive protein, ESR) may be increased during a febrile episode, but not between episodes. Neutropenia or other symptoms (. Eg diarrhea, rash, cough) are not typical; their presence indicates a different disease. Treatment Treatment is optional, it can glucocorticoids, cimetidine, and rarely include tonsillectomy. Patients tend to outgrow this syndrome without sequelae.

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