The pharmacodynamics of a drug can be affected by physiological changes due to

Pharmacodynamics (sometimes described as “making the drug to the body”), is the study of biochemical, physiological and molecular effects of drugs on the body and comprises the receptor binding (including receptor sensitivity), and chemical effects post-receptor interactions. Together with the pharmacokinetics (what the body with the drug or the effect of a drug in the body [1-2]) helps the pharmacodynamics, the relationship between dose and response, d. H. To understand the effect of drugs. The pharmacological response depends on the binding of the drug from to its target structure. The concentration of the drug at the receptor influences its effect. The pharmacodynamics of a drug can be affected by physiological changes due to a disturbance aging more drugs diseases that affect the pharmacodynamic response include genetic mutations, hyperthyroidism, malnutrition, myasthenia gravis, Parkinson’s disease and some forms of insulin-resistant diabetes mellitus. These disorders can also change the receptor binding or the amount of the binding proteins or reduce the sensitivity of the receptor. Getting older seems tend to have an influence on the pharmacodynamic response by receptor binding or sensitivity of the post-receptor reaction change (see table: effects of aging on drug reaction). Pharmacodynamic drug-drug interactions lead to competition for receptor binding sites, or alter the post-receptor reaction. Notes Hughes G. Friendly pharmacokinetics: a simple introduction. Nurse Prescribing 14 (1): 34-43, 2016. Aymanns C, Keller F, mouse S, et al. Review of pharmacokinetics and pharmacodynamics and the aging kidney. Clin J Am Soc Nephrol 5 (2): 314-327, doi 2010.: 10.2215 / CJN.03960609.

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