Overview Of Eosinophilic Lung Disease

Eosinophilic lung diseases are a heterogeneous group of diseases that are characterized by an accumulation of eosinophils in the alveoli and / or the interstitial space. Also peripheral eosinophilia occurs frequently. Among the known causes of eosinophilic lung disease include infection (especially helminth infections) drug-induced pneumonia (eg., Therapeutic drugs, such as antibiotics, phenytoin or l-tryptophan) Inhaled toxins (eg. As “recreational drugs” such as cocaine) Systemic diseases (eg. B. eosinophilic granulomatosis with polyangiitis [formerly Churg-Strauss syndrome]) allergic bronchopulmonary aspergillosis Often the cause is unknown. The two primary eosinophilic lung disease of unknown etiology Acute eosinophilic pneumonia Chronic eosinophilic pneumonia The hypereosinophilic syndrome, a systemic disease that affects many organs is explained in more detail elsewhere. The Löffler’s syndrome, a syndrome of volatile findings lung and peripheral blood eosinophilia, eosinophilic weiterere is a lung disease. Diagnostic x-ray thorax Demonstrate eosinophilia in peripheral blood, of the bronchoalveolar lavage fluid or in the lung tissue, the diagnosis is based on the detection of shadows in the chest X-ray and the detection of eosinophilia (> 450 / ul) in peripheral blood, BAL or lung biopsy. However, pulmonary eosinophilia can occur without peripheral eosinophilia. Pulmonary shading in the X-ray image associated with eosinophilia sometimes referred to as PIE (pulmonary infiltration with eosinophilia) syndrome. Eosinophils are primarily fabric permanent cells, and their number in tissues is 100-fold greater than in the blood. Accordingly show Bluteosinophilenzahlen not necessarily to the extent of Eosinophilenbeteiligung in affected tissues. Eosinophils are the most numerous before in tissues that have an epithelial Mukosagrenzfläche with the environment, such as respiratory, digestive and urogenital tract lower. Eosinophils do not occur in the lungs of healthy people, so their presence indicates in lung tissues or BAL fluid (> 5% of the differential count) to a pathological process. Eosinophilic react very sensitive to corticosteroids and disappear within a few hours of corticosteroids completely from the blood. This rapid disappearance from the blood can complicate the diagnosis when patients receive corticosteroids before the diagnosis is established.