The preservation of the serum magnesium concentration is essentially a combination of magnesium dietary intake and an effective renal and intestinal preservation. Within 7 days after the start of a magnesium diet containing magnesium concentrations fall in feces and urine to about 12.5 mg / day (0.5 mmol / day) from.
Magnesium is the cation which is present in the body at the fourth most common. An adult with a body weight of 70 kg has about 2000 mEq magnesium. Approximately 50% of these are built into the bones and are not easy to exchange with magnesium in other components. The ECF contains about 1% of total body magnesium. The remainder is in the intracellular compartment. Normal serum magnesium concentrations are in the range of 1.8-2.6 mEq / l (0.74 to 1.07 mmol / l). The preservation of the serum magnesium concentration is essentially a combination of magnesium dietary intake and an effective renal and intestinal preservation. Within 7 days after the start of a magnesium diet containing magnesium concentrations fall in feces and urine to about 12.5 mg / day (0.5 mmol / day) from. Approximately 70% of the serum magnesium are filtered in the kidney, the rest is bound to proteins. Protein binding of magnesium is pH-dependent. Serum magnesium concentration depends on both the total body magnesium content and with the intracellular magnesium concentration is not closely related. However, a severe hypomagnesemia may indicate a reduced total body magnesium content in serum. Hypermagnesemia is most commonly caused by kidney failure. Many enzymes are activated by magnesium or are dependent on magnesium. Magnesium is in all enzymatic processes including where ATP is involved, and of many enzymes that play a role in nucleic acid metabolism required. Magnesium is needed for thiamine pyrophosphate cofactor activity and appears to be the structure of macromolecules such as DNA and RNA to stabilize. Magnesium is also very closely related to the metabolism of calcium and potassium, what it but so far there is little exact knowledge.