(Mucosal pemphigoid, ocular mucous membrane pemphigoid, Cicatricial Pemphigoid, cicatricial ocular pemphigoid, mucous membrane pemphigoid benign)
The ocular pemphigoid is a chronic, bilateral, progressive scarring and shrinkage of the conjunctiva with corneal opacity. Early symptoms are hyperemia, itching, secretion production and an uncomfortable feeling in the eye area. The progression of the disease leads to eyelid and corneal damage and sometimes blindness. The diagnosis is confirmed by biopsy sometimes. Systemic Immunsuppressivatherapie is often required.
The ocular pemphigoid is a chronic, bilateral, progressive scarring and shrinkage of the conjunctiva with corneal opacity. Early symptoms are hyperemia, itching, secretion production and an uncomfortable feeling in the eye area. The progression of the disease leads to eyelid and corneal damage and sometimes blindness. The diagnosis is confirmed by biopsy sometimes. Systemic Immunsuppressivatherapie is often required.
(See also mucous membrane.) The ocular pemphigoid is a chronic, bilateral, progressive scarring and shrinkage of the conjunctiva with corneal opacity. Early symptoms are hyperemia, itching, secretion production and an uncomfortable feeling in the eye area. The progression of the disease leads to eyelid and corneal damage and sometimes blindness. The diagnosis is confirmed by biopsy sometimes. Systemic Immunsuppressivatherapie is often required. The ocular pemphigoid is an autoimmune disease in which the binding of the conjunctival anti-basement membrane antibodies leads to a conjunctivitis. A connection to the bullous pemphigoid not exist. Symptoms and signs In general, the scarring pemphigoid begins as chronic conjunctivitis with nonspecific hyperemia without drainage in certain quadrants and then evolving a symblepharon (adhesions between the tarsal and bulbar conjunctiva) to trichiasis (inward turning of the eyelashes), keratoconjunctivitis sicca, corneal – (neovascularization, turbidity and keratinization) and conjunctival changes (shrinkage and keratinization). Chronic Hornhautepitheldefekte can lead to a secondary bacterial ulceration, scarring and blindness. An involvement of the oral mucosa (with ulceration and scarring) is common, while a skin involvement is rare (with typical scarring bullae and erythematous plaques). Diagnosis unexplained symblepharon or findings of a biopsy The diagnosis of ocular mucous membrane pemphigoid is suspected clinically in patients with conjunctival and corneal changes symblepharon or both. For differential diagnosis in relation to the progressive conjunctival scarring previous radiation exposure and atopic diseases must be recorded. Thus, the clinical diagnosis of scarring pemphigoid is made when a progressive symblepharon without local irradiation or severe perennial allergic conjunctivitis is present in the history. The diagnosis is confirmed by a conjunctival biopsy at which antibody deposits can be detected in the basement membrane. However, a negative biopsy does not exclude the diagnosis. Ocular mucous Image courtesy of O. H. Gottfried Naumann about the Online Journal of Ophthalmology (www.onjoph.com). var model = {thumbnailUrl: ‘/-/media/manual/professional/images/cicatrical_pemphigoid_orig_de.jpg?la=de&thn=0&mw=350’ imageUrl: ‘/-/media/manual/professional/images/cicatrical_pemphigoid_orig_de.jpg?la = en & thn = 0 ‘, title:’ Ocular Mucosal ‘description:’ u003Ca id = “v37894177 ” class = “”anchor “” u003e u003c / a u003e u003cdiv class = “”para “” u003e u003cp u003eEin ocular mucous is an autoimmune disease (a connection to bullous pemphigoid is not) cause a chronic conjunctivitis with the autoantibodies