Nonspecific Interstitial Pneumonia

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The nonspecific interstitial pneumonia is an idiopathic interstitial pneumonia, the <50 years old occurs mainly in women, nonsmokers and patients.

Compared with idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP) is a rare idiopathic interstitial pneumonia. Most patients are women, aged between 40 and 50, and there is no known cause or known relationship. However, a similar pathologic process in patients (in particular systemic sclerosis or polymyositis / dermatomyositis) occur with a connective tissue disease, some forms of drug-induced lung injury and patients with hypersensitivity pneumonitis.

The nonspecific interstitial pneumonia is an idiopathic interstitial pneumonia, the <50 years old occurs mainly in women, nonsmokers and patients. Compared with idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP) is a rare idiopathic interstitial pneumonia. Most patients are women, aged between 40 and 50, and there is no known cause or known relationship. However, a similar pathologic process in patients (in particular systemic sclerosis or polymyositis / dermatomyositis) occur with a connective tissue disease, some forms of drug-induced lung injury and patients with hypersensitivity pneumonitis. The clinical picture is similar to that of IPF. Cough and dyspnea persist for months to years. General symptoms are unusual, however, low-grade fever and malaise are possible. Diagnosis High-resolution CT (HRCT) Surgical lung biopsy The diagnosis should be considered in patients with unexplained subacute or chronic cough and shortness of breath into consideration. The diagnosis requires a HRCT and must always be confirmed by surgical lung biopsy. NSIP is a diagnosis of exclusion, which requires a careful clinical examination of possible alternative diseases, especially connective tissue diseases, hypersensitivity pneumonitis and Arzneimittelintoxikation. The chest X-ray shows primarily reticular pattern in the subfields. Also bilateral patchy opacities may be possible. Among the findings of HRCT bilateral patchy ground glass opacities, irregular lines and bronchial dilation include (Traktionsbronchiektasen), usually with a distribution in the lower lung area. Subpleural sparing is possible. A honeycomb lung is rare. More than half of patients have an increased percentage of lymphocytes in BAL fluid, but this finding is nonspecific. Idiopathic nonspecific interstitial pneumonia Image courtesy of Harold R. Collard, M.D. var model = {thumbnailUrl: '/-/media/manual/professional/images/idiopathic_nonspecific_interstitial_pneumonia_high_de.jpg?la=de&thn=0&mw=350' imageUrl: '/-/media/manual/professional/images/idiopathic_nonspecific_interstitial_pneumonia_high_de.jpg?la = en & thn = 0 ', title:' Idiopathic nonspecific interstitial pneumonia ', description:' u003Ca id = "v37893180 " class = ""anchor "" u003e u003c / a u003e u003cdiv class = ""para "" u003e u003cp u003eIn this high-resolution CT scan can be seen predominantly subpleural and basal frosted glass opacities. The relative recess of the lungs directly beneath the pleural surface is typical of a non-specific interstitial pneumonia u003c / p u003e u003c / div u003e 'credits'. Image courtesy of Harold R. Collard

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