NMO is a demyelinating disease only the eyes and spinal cord.
(Siaha also Overview of demyelinating diseases.)
NMO is a demyelinating disease only the eyes and spinal cord. (Siaha also Overview of demyelinating disease.) It causes a sometimes bilateral acute optic neuritis plus demyelination of the cervical and thoracic cord. NMO was once considered a variant of multiple sclerosis (MS), but today it is considered a separate disease. Symptoms include loss of vision, muscle spasms, paraplegia or quadriplegia and incontinence. Diagnosis MRI evoked brain and spinal cord Visually potential The diagnosis of neuromyelitis optica usually includes an MRI of the brain and spinal cord and visual evoked potentials. NMO is distinct from MS because it affects several contiguous spinal segments of the spinal cord, whereas MS affects usually on a single segment. Also cerebral white matter lesions are rare in neuromyelitis optica, unlike MS. Blood tests for the detection of for Neuromyelitis optica (Aquaporin-4 Antibodies [also known as NMO-IgG] specific IgG antibody NMO-IgG) can be carried out in order to distinguish these interference from an MS. Treatment corticosteroids and immunomodulatory or immunosuppressive treatments There is no cure. However, treatment can prevent flare-ups, slow down or reduce their severity. Methylprednisolone and azathioprine are often used together. Plasma exchange may help people who do not respond to corticosteroids. Rituximab, an anti-B-cell antibody, reduced IgG production, and appears to stabilize the disease. The symptomatic treatment equivalent to that in MS. Baclofen or tizanidine can relieve muscle spasms.