The myeloproliferative disorders are abnormal proliferation of bone marrow stem cells, which can manifest as increased number of platelets, red blood cells or leukocytes in the blood circulation and sometimes as an increased fibrosis in the bone marrow. Based on these anomalies are classified as essential thrombocythemia (increased platelet) Primary myelofibrosis (bone marrow fibrosis or scarring) polycythemia vera (increased erythrocytes) Chronic myeloid leukemia (increased leukocyte Chronic myeloid leukemia (CML)) Essential Thrombocythemia, primary myelofibrosis, and polycythemia vera are Philadelphia chromosome-negative myeloproliferative disorders. Myeloproliferative disorders, particularly chronic myeloid leukemia, acute leukemia sometimes have a result; the WHO classification also assigns hypereosinophilic syndrome and mastocytosis the group of myeloproliferative disorders. (Editor’s note: WHO classification. Chronic myeloproliferative neoplasms) There are also rare myeloproliferative disorders that overlap with myelodysplastic syndrome (myelodysplastic syndrome). The individual diseases may according to their prevailing characteristics or the type of proliferating cells (see Table: Classification myeloproliferative diseases) are diagnosed. Despite similarities more or less typical clinical symptoms and laboratory values ??and a characteristic curve associated with each myeloproliferative disease. Although the clinical picture may be dominated by the proliferation of a cell line, all of which are typically caused these diseases by clonal proliferation of a pluripotent stem cell, is caused by the abnormal proliferation of erythroid, myeloid, and megakaryocytic precursors in the bone marrow in varying degrees. However, this abnormal clone does not produce bone marrow fibroblasts proliferate reactive and polyclonal. The result of a mutation of the activated tyrosine kinase JAK2 supports the development of polycythemia vera and is involved in erythropoietin to the bone marrow response. With a large number of essential thrombocythemia and myelofibrosis is also mutated. Classification of myeloproliferative diseases Disease The predominant feature of polycythemia vera myelofibrosis erythrocytosis Primary myelofibrosis with extramedullary hematopoiesis Essential thrombocythemia thrombocytosis Chronic myeloid leukemia granulocytosis

Health Life Media Team

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