(Myeloma kidney myeloma cast nephropathy)
Multiple myeloma patients suffering from an overproduction of free monoclonal Ig light chains (Bence Jones proteins). These chains are filtered by the glomeruli. You are nephrotoxic and can – in its various forms (free, tubular cylinder, amyloid) – practically all regions of the renal damage. Diagnosis is made by urine tests (Sulfosalicylsäuretest or protein electrophoresis) or renal biopsy. The treatment focuses on the multiple myeloma and a sufficient flow of urine. Myeloma-induced kidney disease are rarely caused by Ig heavy chains.
Tubulointerstitial disease and glomerular damage are the most common forms of kidney damage. The mechanisms by which the light chain directly damage the nephrons are unknown. Hypercalcemia contributes to renal failure by a decrease in renal blood flow.
Multiple myeloma patients suffering from an overproduction of free monoclonal Ig light chains (Bence Jones proteins). These chains are filtered by the glomeruli. You are nephrotoxic and can – in its various forms (free, tubular cylinder, amyloid) – practically all regions of the renal damage. Diagnosis is made by urine tests (Sulfosalicylsäuretest or protein electrophoresis) or renal biopsy. The treatment focuses on the multiple myeloma and a sufficient flow of urine. Myeloma-induced kidney disease are rarely caused by Ig heavy chains. Tubulointerstitial disease and glomerular damage are the most common forms of kidney damage. The mechanisms by which the light chain directly damage the nephrons are unknown. Hypercalcemia contributes to renal failure by a decrease in renal blood flow. Tubulointerstitial disease types of tubulo-interstitial kidney disease in multiple myeloma are myeloma kidney ( “myeloma cast nephropathy”) Acquired Fanconi syndrome (disease of the proximal tubule) Interstitial deposition in the light chain, thereby acute tubular necrosis is caused Light chains saturate the reabsorptive capacity of the proximal tubules, reach the distal nephron, combine with proteins filtered and Tamm-Horsfall mucoproteins (secreted by the cells of the thick ascending limb) and form obstructing cylinder. The term myeloma kidney or Cast nephropathy generally refers to the renal failure, which is caused by the resulting tubulointerstitial damage. Low urine flow x-ray contrast media hyperuricemia NSAIDs Increased intratubuläres calcium increase in luminal sodium chloride concentration (eg due to a loop diuretic.) Due to hypercalcemia, often as a result of bone lysis in multiple: the factors that predispose to the formation of cylinder formations include the following myeloma occurs. Myeloma kidney imaging provided by Agnes Fogo, M.D., and the American Journal of Kidney Disease, Atlas of Renal Pathology (see www.ajkd.org). var model = {thumbnailUrl: ‘/-/media/manual/professional/images/myeloma_kidney_high_de.jpg?la=de&thn=0&mw=350’ imageUrl: ‘/-/media/manual/professional/images/myeloma_kidney_high_de.jpg?la = en & thn = 0 ‘, title:’ myeloma kidney ‘, description:’ u003Ca id = “v38397004 ” class = “”anchor “” u003e u003c / a u003e u003cdiv class = “”para “” u003e u003cp u003eMyelomniere refers to a tubulointerstitial disease that is caused by light chain deposition and obstructive cylinder formation in the renal tubules. The biopsy shows Tubuluszylinder with surrounding Synzytio giant cell response