Many relatively common congenital malformations and familial syndromes are the result of a multifactorial inheritance. The affected persons the sum of genetic and environmental influences in disease is expressed. A disease or disorder is far more likely in first-degree on (siblings, parents or children whose genes correspond to 50% with an interested party), while more distant relatives have probably inherited a few high-risk genes.

Several genes are involved in the expression of many traits. Many of these characteristics (eg. B. size) are arranged along a bell-shaped curve distribution (normal distribution). Each gene normally contributes independently of other genes for characteristic value at or weakens them off. In this pattern of distribution are only a few people at the two ends of the curve and most in the middle, as it is unlikely that multiple genetic factors all affect in the same direction. Environmental factors can increase the expression or weaken. Many relatively common congenital malformations and familial syndromes are the result of a multifactorial inheritance. The affected persons the sum of genetic and environmental influences in disease is expressed. A disease or disorder is far more likely in first-degree on (siblings, parents or children whose genes correspond to 50% with an interested party), while more distant relatives have probably inherited a few high-risk genes. Common diseases with multifactorial inheritance are high blood pressure, coronary heart disease, type 2 diabetes, cancer, cleft palate and arthritis. Many specific genes that contribute to these properties are, by the most sensitive available genetic testing identified (called “Next Generation Sequencing” – Diagnostic genetic method) to test people with and without the mutation characteristics. On the basis of genetically determined predisposing factors (including family history and biochemical pathways that are often identified by molecular markers, such. As high cholesterol) can identify those at risk who benefit most from preventive measures. Polygenic multifactorial features rarely produce clear pattern of inheritance, however, these features appear more frequently in certain ethnic and geographic groups or within the one or other sex act.

Health Life Media Team

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