Aztreonam is currently the only available monobactam. Aztreonam is as effective as ceftazidime against

Monobactams are parenteral bactericidal ?-lactam antibiotics. Aztreonam is currently the only available monobactam. Aztreonam is as effective as ceftazidime against enterobacteria, which do not produce ?-lactamase ampC or Extended-spectrum ?-lactamase (ESBL) Pseudomonas aeruginosa Aztreonam is not effective against anaerobes. Gram-positive bacteria are resistant to aztreonam (as opposed to cephalosporins). Aztreonam acts synergistically with aminoglycosides. The metabolites of aztreonam differ from those of other ?-lactams, therefore a cross-hypersensitivity is unlikely. Thus, aztreonam is mainly used for Heavy aerobic gram-negative bacterial infections, including meningitis, in patients with severe allergy to ?-lactams, but still need a ?-lactam therapy. Other antibiotics are also given to cover Gram-positive cocci and anaerobes with suspicion. The dose is reduced in renal failure.

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