Mesothelioma

The pleural mesothelioma is the only known pleura is almost always caused by asbestos exposure. Diagnosis is based on medical history and Röntgenthoraxbild- or CT findings and confirmed by biopsy. The treatment is supportive, which may require surgery, chemotherapy or both.

Asbestos is the generic term for naturally occurring fibrous silicates, which are well suited due to their heat resistance and structural properties as construction materials for buildings and ships, automotive brakes and some textiles. Chrysotile (a Serpentinfaser), crocidolite and amosite (amphibole or straight fibers) are the 3 main groups of disease-causing asbestos.

The pleural mesothelioma is the only known pleura is almost always caused by asbestos exposure. Diagnosis is based on medical history and Röntgenthoraxbild- or CT findings and confirmed by biopsy. The treatment is supportive, which may require surgery, chemotherapy or both. Asbestos is the generic term for naturally occurring fibrous silicates, which are well suited due to their heat resistance and structural properties as construction materials for buildings and ships, automotive brakes and some textiles. Chrysotile (a Serpentinfaser), crocidolite and amosite (amphibole or straight fibers) are the 3 main groups of disease-causing asbestos. Asbestos workers have a lifelong risk of disease mesothelioma to develop up to 10% with an average latency of 30 years. The risk is independent of smoking. Mesothelioma can grow locally or metastasize to hilar and mediastinal lymph nodes, pericardium, diaphragm, peritoneum, liver, adrenal glands or kidneys and, rarely, in the tunica vaginalis of the testis. Symptoms and signs Most often the patients present with dyspnea and chest pain nichtpleuritischen. General symptoms are rare at the time of initial presentation. Infiltration into the chest wall and other adjacent structures can cause severe pain, hoarseness, dysphagia, Horner syndrome, paralysis of the brachial plexus or ascites. Diagnostic chest X-ray cytology of pleural fluid or pleural Sometimes video-assisted thoracoscopy (VATS), or thoracotomy staging with chest CT, mediastinoscopy and MRI or sometimes with PET and bronchoscopy The pleural variant of mesothelioma, which is present in> 90% of cases (pericardial include 10% peritoneal mesotheliomas a) shows up on X-ray as diffuse unilateral or bilateral pleural thickening, which seems to wall the lungs and usually leads to enlargement of costophrenic angle. Pleural effusions are present in 95% of cases, typically one-sided, solid and hemorrhagic. Diagnosis is based on cytology of pleural fluid or pleural biopsy. Elevated levels of hyaluronidase in pleural fluid indicate mesothelioma, but are not diagnostic. When the diagnosis by this method is uncertain, biopsy means VATS or a thoracotomy is performed. In ongoing studies, soluble mesothelin-related proteins that are released by mesothelial cells to serum studied as potential tumor markers for diagnosis and monitoring of the disease, but false positives can limit their effectiveness. The staging consists of a chest CT, mediastinoscopy and an MRI. Sensitivity and specificity of MRI and CT are similar, although the MRI is better suited to determine the extent of the tumor in the spine and the spinal cord. The PET may have a higher sensitivity and specificity for differentiating benign and malignant pleural thickening. By bronchoscopy can be excluded coexisting endobronchial lung cancer. Pleural mesothelioma with permission of the publisher. From Huggins J., S. Sahn In Bone’s Atlas of Pulmonary and Critical Care Medicine. Edited by J. Crapo. Philadelphia, Current Medicine, 2005. var model = {thumbnailUrl: ‘/-/media/manual/professional/images/malignant_mesothelioma_high_de.jpg?la=de&thn=0&mw=350’ imageUrl: ‘/ – / media / manual / professional / images / malignant_mesothelioma_high_de.jpg lang = en & thn = 0 ‘, title:’? pleural mesothelioma ‘, description:’ u003Ca id = “v37893143 ” class = “”anchor “” u003e u003c / a u003e u003cdiv class = “”para “” u003e u003cp u003eDer chest x-ray of a patient with pleural mesothelioma is pleural thickening with nodular lesions on the parietal pleura u003c / p u003e u003c / div u003e. ‘credits’ with the approval of publisher. From Huggins J.

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