Merkel Cell Carcinoma

(Neuroendocrine carcinoma, small cell carcinoma of the skin; Trabecular carcinoma; APUDom the skin; anaplastic carcinoma)

Merkel cell carcinoma is a rare, aggressive cancer that primarily affects older, fair-skinned people.

The mean age at diagnosis is 75 years. Merkel cell carcinoma occurs in younger patients with immunosuppression. Other risk factors are cumulative exposure to ultraviolet light, exposure to the Merkel cell polyomavirus, and another cancer (eg. As multiple myeloma, chronic lymphocytic leukemia, melanoma). The spread to the lymph nodes is common.

Merkel cell carcinoma is a rare, aggressive cancer that primarily affects older, fair-skinned people. The mean age at diagnosis is 75 years. Merkel cell carcinoma occurs in younger patients with immunosuppression. Other risk factors are cumulative exposure to ultraviolet light, exposure to the Merkel cell polyomavirus, and another cancer (eg. As multiple myeloma, chronic lymphocytic leukemia, melanoma). The spread to the lymph nodes is common. Symptoms and complaints The lesions are usually firm, shiny, skin-colored or bluish-red, and nodular. Their characteristic clinical findings are rapid growth and the absence of pain and sensitivity. Although Merkel cell carcinoma can occur on skin anywhere, it is most common on sun-exposed areas (eg. As face, upper extremities). Diagnostic biopsy The diagnosis is made by biopsy. Most patients have when setting metastases and the prognosis is poor. Therapy Determined by staging The treatment is based on the determination of the cancer stage and usually includes extensive local excision, usually followed by radiation therapy, lymph node dissection, or both. Chemotherapy may be indicated for metastatic or recurrent carcinoma. Prevention Since Merkel cell carcinoma, a reference to UV exposure appears to be a number of measures are recommended to limit exposure. Avoiding sunlight: seeking shade, minimize outdoor activities between 10 am and 4 pm (when the sun rays are strongest), avoidance of sunbathing the use of tanning beds, the use of protective clothing: long-sleeved shirts, pants and wide-brimmed hats use of sunscreen agents: at least a sun protection factor (SPF) 30 verwendne Breibspektrum with UVA / UVB protection as directed (ie every 2 h and after swimming or perspiration newly apply); Sunscreen should not be used in order to stay in the sun longer

Health Life Media Team

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