Megaloblastic Macrocytic Anemias

The most common cause of megaloblastic anemia is a deficiency of vitamin B12 or folic acid. The ineffective hematopoiesis affects all cell lines, but especially the red cell. The diagnosis is made by blood counts and peripheral blood smear. This reflects a macrocytic anemia with Anisozytose and poikilocytosis, large oval erythrocytes (Makroovalozyten) hypersegmented neutrophils, thrombocytopenia and reticulocytopenia can show. Treatment depends on the underlying disease.

Macrocytes are enlarged erythrocytes with a mean corpuscular volume [MCV]> 100 fL / cell. Macrocytic erythrocytes occur under various clinical conditions, which are often not associated with megaloblastic anemia. The macrocytosis can be caused by megaloblastic or other enlarged erythrocytes (Nichtmegaloblastäre macrocytic anemia). Megaloblasts are large nucleated red blood with loose chromatin. The megaloblastosis precedes the macrocytic anemia.

The most common cause of megaloblastic anemia is a deficiency of vitamin B12 or folic acid. The ineffective hematopoiesis affects all cell lines, but especially the red cell. The diagnosis is made by blood counts and peripheral blood smear. This reflects a macrocytic anemia with Anisozytose and poikilocytosis, large oval erythrocytes (Makroovalozyten) hypersegmented neutrophils, thrombocytopenia and reticulocytopenia can show. Treatment depends on the underlying disease. Macrocytes are enlarged erythrocytes with a mean corpuscular volume [MCV]> 100 fL / cell. Macrocytic erythrocytes occur under various clinical conditions, which are often not associated with megaloblastic anemia. The macrocytosis can be caused by megaloblastic or other enlarged erythrocytes (Nichtmegaloblastäre macrocytic anemia). Megaloblasts are large nucleated red blood with loose chromatin. The megaloblastosis precedes the macrocytic anemia. Nichtmegaloblastäre macrocytic anemia macrocytosis in liver disease with permission of the publisher. From Tefferi A., Li C. In Atlas of Clinical Hematology. Edited by J. O. Armitage. Philadelphia, Current Medicine, 2004. var model = {thumbnailUrl: ‘/-/media/manual/professional/images/macrocytosis_in_liver_disease_high_de.jpg?la=de&thn=0&mw=350’ imageUrl: ‘/ – / media / manual / professional / images / macrocytosis_in_liver_disease_high_de.jpg lang = en & thn = 0 ‘, title:’? Makrozytose with liver disease ‘, description:’ u003Ca id = “v38395980 ” class = “”anchor “” u003e u003c / a u003e u003cdiv class = “”para “” u003e u003cp u003eDieses picture shows nonnutritional macrocytic anemia

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