Mastocytosis

Mastocytosis is a mast cell infiltration of the skin or other tissues and organs. The symptoms are mainly due to the release of mediators and express themselves as pruritus, flushing and dyspepsia due to increased gastric acid secretion. The diagnosis is made by skin or bone marrow biopsies or both. The treatment consists of the administration of antihistamines and in the control of underlying diseases.

Mastocytosis comprises a group of diseases that are characterized by the proliferation of mast cells and infiltration of the skin and other organs or both. The disease is mainly due to the release of mast cell mediators, including histamine, heparin, leukotrienes and various inflammatory cytokines. For many symptoms, including the gastrointestinal symptoms, histamine is blamed, but other mediators contribute to symptoms. A significant organ infiltration can lead to organ dysfunction. The release of mediators can be triggered by physical contact, physical exertion, alcohol, NSAIDs, opioids, insect bites or food.

Mastocytosis is a mast cell infiltration of the skin or other tissues and organs. The symptoms are mainly due to the release of mediators and express themselves as pruritus, flushing and dyspepsia due to increased gastric acid secretion. The diagnosis is made by skin or bone marrow biopsies or both. The treatment consists of the administration of antihistamines and in the control of underlying diseases. Mastocytosis comprises a group of diseases that are characterized by the proliferation of mast cells and infiltration of the skin and other organs or both. The disease is mainly due to the release of mast cell mediators, including histamine, heparin, leukotrienes and various inflammatory cytokines. For many symptoms, including the gastrointestinal symptoms, histamine is blamed, but other mediators contribute to symptoms. A significant organ infiltration can lead to organ dysfunction. The release of mediators can be triggered by physical contact, physical exertion, alcohol, NSAIDs, opioids, insect bites or food. The etiology includes many patients an activating mutation (D816V) in the gene encoding the stem cell factor receptor c-kit, which can be found on mast cells. The result is autophosphorylation of the receptor, which in turn causes an uncontrolled mast cell proliferation. Classification Mastocytosis may be cutaneous or systemic. Cutaneous mastocytosis Typically developing children to this type. Most patients suffering from urticaria pigmentosa, which spread through local or diffuse, is characterized small multiple mast cell clusters in the form of salmon-colored or brown maculopapular rashes. Less frequently occur: the diffuse cutaneous mastocytosis, a skin infiltration without discrete lesions, and mastocytoma, a large (1-5 cm) accumulation of mast cells. Urticaria pigmentosa with permission of the publisher. From Joe E., Soter N. In Current Dermatologic Diagnosis and Treatment, edited by I. Freedberg, I.M. Freedberg and M. R. Sanchez. Philadelphia, Current Medicine, 2001. var model = {thumbnailUrl: ‘/-/media/manual/professional/images/urticaria_pigmentosa_high_de.jpg?la=de&thn=0&mw=350’ imageUrl: ‘/ – / media / manual / professional / images / urticaria_pigmentosa_high_de.jpg lang = en & thn = 0 ‘, title:’? urticaria pigmentosa ‘description:’ u003Ca id = “v37895588 ” class = “”anchor “” u003e u003c / a u003e u003cdiv class = “”para “” u003e u003cp u003eLäsionen consist of reddish-brown

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