Marchiafava-Bignami Disease

The Marchiafava-Bignami disease is a rare demyelination of the corpus callosum, which occurs in chronic alcoholics, preferably in men.

See also alcohol toxicity and cessation as well as alcohol use disorder and rehabilitation.)

The Marchiafava-Bignami disease is a rare demyelination of the corpus callosum, which occurs in chronic alcoholics, preferably in men. See also alcohol toxicity and cessation as well as alcohol use disorder and rehabilitation.) Neuropathologically and pathophysiological there is overlap with the osmotic Demyelinisierungssyndrom (formerly known as central pontine myelinolysis. When Marchiafava-Bignami disease, the speed of onset and degree of physical findings vary. The patients can show an acute, subacute or chronic onset of mental status change from lethargy to coma, seizures, eye movement disorders, memory loss and gait disturbance. Some patients get better after several months. for patients in a coma or stupor, the mortality rate is about 20%. It is no specific treatment, but the supportive treatment typically comprises vitamin supplement (in particular of thiamine, folate, and other B vitamins) and correcting malnutrition.

Health Life Media Team

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