An infection can manifest themselves locally (eg. B. cellulitis, abscess) or systemically, usually by fever. It can also come in several organ systems to manifestations. Severe, generalized infections can have life-threatening complications (eg. As sepsis, septic shock). Most manifestations are resolved by a successful treatment of the underlying disease. Clinical Most infections cause an increase in heart rate and body temperature at some other (eg. As typhoid fever, tularemia, brucellosis and dengue fever) but is not usually a fever adequate increase in pulse rate. Hypotension may occur as a result of hypovolemia, septic shock or toxic shock. There is often a hyperventilation and respiratory alkalosis. Sensory changes (encephalopathy) can occur even without a cerebral infection in severe infections. They are most often and most pronounced in older people and cause anxiety, confusion, delirium, stupor, convulsions and coma. Hematological infectious diseases lead of mature and immature circulating neutrophils usually to the increase. When doing so, Demargination and release of immature granulocytes from the bone marrow, the IL-1 and IL-6-mediated release of neutrophils from the bone marrow, as well as the release of colony stimulating factor by macrophages, lymphocytes and other cell types. An excessive reaction (eg. As in trauma, infection and similar situations of stress) can result in excessive release of immature leukocytes in the blood circulation (leukemic reaction), with leukocyte up to 25-30 x 109 / l. In contrast, some infections (eg. As typhoid fever, brucellosis) usually cause leukopenia. In fulminant, severe infections a significant leukopenia is often an unfavorable prognostic sign. In neutrophils septic patients characteristic morphological changes (Döhle bodies, toxic granulations, vacuolization) are observed. Anemia can develop despite adequate tissue iron levels. If anemia is chronic, the plasma iron and total iron binding capacity may be lowered. S chwere infections can one Thrombozytopeniae and a coagulation (DIC) cause. Other organ systems, the lung compliance can be reduced and an acute respiratory distress syndrome (ARDS) and develop into a muscular respiratory failure. Renal manifestations range from a minimum proteinuria to acute renal failure, which can be triggered by the shock, acute tubular necrosis, glomerulonephritis or tubulointerstitial disease. Liver dysfunction, including cholestatic jaundice (often a prognostically unfavorable sign) or hepatocellular dysfunction, occur in many infectious diseases, even if the pathogen is not localized in the liver. Bleeding of the upper gastrointestinal tract can also occur during sepsis due to stress ulcers. Endocrinological dysfunctions Increased production of thyroid stimulating hormone, vasopressin, insulin, and glucagon degradation of skeletal muscle proteins and muscle wasting secondary to increased metabolic demands bone demineralization hypoglycemia rarely occurs in sepsis, but adrenal insufficiency should be considered in patients with hypoglycemia and sepsis into consideration. Hyperglycemia can be an early sign of infection in diabetics.