Lymphomas are a heterogeneous group of tumors that arise from the reticuloendothelial and lymphatic system. The main representatives are Hodgkin’s disease and non-Hodgkin’s lymphoma (NHL comparison between Hodgkin’s and non-Hodgkin’s lymphoma). Comparison between Hodgkin’s and non-Hodgkin’s lymphoma feature Hodgkin’s Lymphoma Non-Hodgkin lymphoma lymph node involvement on a specific lymph node group located usually extended to> 1 nodal group spread tendency to orderly, continuous propagation Non-continuous spread involvement of Waldeyer ring and the mesenteric lymph node Usually no involvement Affects often mesenteric lymph nodes Waldeyer ring can infect Extranodal participation Rarely Frequently stage at diagnosis typically early stage usually advanced stage Histological Classification in children usually favorable prognosis usually highly malignant Previou ago it was assumed that lymphomas differ strictly by the leukemia. Through a better understanding of cellular markers and precise methods for determining these markers can now be shown but that the distinction between these two malignancies is often blurred. The idea that lymphoma – at least in the early stages – are limited to the lymphatic system, and leukemia in the bone marrow, is also not always correct.