Linezolid And Tedizolid

Linezolid and Tedizolid are oxazolidinone antibiotics (lincosamides, oxazolidinones and streptogramins). Linezolid Linezolid is an oxazolidinone antibiotic that is effective against the following pathogens: Streptococcus enterococci (Enterococcus faecalis and E. faecium) staphylococci, including strains that are resistant to other classes of antibiotics. Mycobacteria anaerobes such as Fusobacterium, Prevotella, Porphyromonas, and Bacteroides spp. and Peptostreptococci contraindications Linezolid is who in the past allergic responded contraindicated in patients. Other contraindications are risk factors for the serotonin syndrome or Hypertonie.Serotoninsyndrom Linezolid is a reversible, non-selective Monaminoxidasehemmer (MAOIs); MAO inhibition leads to an increase in levels of the neurotransmitter serotonin. Thus, linezolid has the potential to the serotonin syndrome causing, when it is used in patients with one of the following conditions (designated by mental status changes, neurological abnormalities and autonomic instability actual serotonin syndrome which a hyperserotonerger state): Endocrine active carcinoid tumors (Overview to carcinoid tumors) use of drugs with activity hyperserotonerger These drugs include SSRIs, MAOIs (z. B. phenelzine, isocarboxazid), tricyclic antidepressants, serotonin 1B, 1D receptor agonists (triptans), meperidine, bupropion and buspirone. Patients taking these drugs and urgently need linezolid can be treated if it is assumed that the benefit outweighs the risk, and if they settle the proserotonerge drug immediately carefully on manifestations of serotonin syndrome for 2 weeks after stopping the drug be monitored (5 weeks for fluoxetine) or 24 hours after the last dose of linezolid linezolid has not been studied in patients with carcinoid syndrome; it should only be used when the patient werden.Hypertonie carefully monitored for signs and symptoms of serotonin syndrome, linezolid should not be given to the following patients, unless they are obs to rule out hypertension: patients taking any of the following drugs: sympathomimetics (z., pseudoephedrine), vasopressors (z. B. adrenaline, noradrenaline) or dopaminergic drugs (eg. as dopamine, dobutamine) patients with uncontrolled hypertension patients with hyperthyroidism patients with pheochromocytoma use during pregnancy and lactation linezolid is in the pregnancy category C (animal studies show some risk indications in human studies are insufficient, but sometimes clinical benefit outweighs the risk). Whether linezolid is excreted into breast milk during lactation is safe, is not bekannt.Nebenwirkungen Side effects include reversible myelosuppression irreversible peripheral neuropathy reversible optic neuropathy serotonin syndrome At approximately 3% of patients (usually with treatment duration> 2 weeks) to be a reversible myelosuppression including thrombocytopenia, leukopenia and anemia. For this reason, a weekly blood counts should, especially in a therapy> 2 weeks, are performed. Peripheral and optic neuropathy can occur with prolonged use, and patients who are undergoing long-term linezolid therapy should be monitored closely for these disorders go. Tedizolid Tedizolid is an oxazolidinone antibiotic with a spectrum of activity that is similar to that of linezolid, although it can be effective against some of linezolid-resistant Gram-positive cocci. In clinical trials, the risk was lower for serotonin syndrome and thrombocytopenia with Tedizolid as linezolid. Tedizolid can cause significant neutropenia and its use is not in patients with a neutrophil granulocyte count of <1,000 cell / mm3 recommended.

Health Life Media Team

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