Kalziumpyrophosphatdihydrat-Form Of Crystal

(Pseudogout)

The Kalziumpyrophosphatdihydrat- (CPPD) form of crystal is characterized by intra-articular and / or extra-articular deposition of CPPD crystals. The manifestations are varied, they can be minimal pronounced or there is intermittent attacks of acute arthritis, pseudogout or acute Kalziumyrophosphat crystal illness called degenerative arthropathy and one that can become significant. Diagnosis requires the detection of CPPD crystals in the synovial fluid. The treatment of pseudogout attacks performed with intra-articular corticosteroids or oral corticosteroids, NSAIDs or colchicine.

The CPPD crystal deposition (chondrocalcinosis) whether symptomatic or asymptomatic, is more common with age.

The Kalziumpyrophosphatdihydrat- (CPPD) form of crystal is characterized by intra-articular and / or extra-articular deposition of CPPD crystals. The manifestations are varied, they can be minimal pronounced or there is intermittent attacks of acute arthritis, pseudogout or acute Kalziumyrophosphat crystal illness called degenerative arthropathy and one that can become significant. Diagnosis requires the detection of CPPD crystals in the synovial fluid. The treatment of pseudogout attacks performed with intra-articular corticosteroids or oral corticosteroids, NSAIDs or colchicine. The CPPD crystal deposition (chondrocalcinosis) whether symptomatic or asymptomatic, is more common with age. Asymptomatic chondrocalcinosis is often in the knee, find the metacarpophalangeal joints, wrist, and spine of the symphysis. Men and women are equally affected. Etiology The cause of CPPD deposition disease is not known. The frequent association with other diseases, such as trauma (incl. Surgery), hypomagnesemia, hyperparathyroidism, gout, hemochromatosis and old age suggest that the CPPD deposits occur secondary to degenerative or metabolic disorders in the affected tissue. Some cases are familial, usually autosomal dominant trait with complete penetration at the age of 40 years. Recent studies show that the protein ANK is a key factor in the production of excess extracellular pyrophosphate, which promotes CPPD crystal formation. ANK-protein is a putative transporter of intracellular pyrophosphate to an extracellular location where then form CPPD crystals. Symptoms and complaints It can be an acute, subacute or chronic arthritis occur mostly localized in the knee or in any other large peripheral joints, so the disruption of Kalziumpyrophosphatkristalle a variety of other forms of arthritis can be similar. Acute attacks sometimes resemble a gout, but are usually less severe. The intervals between attacks may be free of symptoms of CPPD deposition disease, also are continuously low inflammatory symptoms in many joints, similar to the RA or osteoarthritis, possible. These patterns seem a lifetime to persist. Diagnostic analysis of synovial fluid Microscopic identification of the crystals A CPPD form of crystal should be suspected in elderly patients with acute arthritis, especially in inflammatory arthritis. The diagnosis of CPPD deposition disease is provided by diamond-identification or rod-shaped crystals in the synovial fluid, which are not birefringent or weakly positively birefringent in polarized light microscopy. Synovial fluid in acute attacks have findings that are typical of inflammation; thus coincident infectious arthritis and gout (other common causes of inflammatory synovial fluid) must also be ruled out. Infectious arthritis is excluded by a Gram stain and culture. Gout can best be generally excluded by the absence of urate crystals in fluid from the inflamed joint. X-rays or ultrasound are indicated if no synovial fluid can be recovered for analysis. Linear or dotted calcification in the articular cartilage, v. a. in fibrocartilage, support the diagnosis, but do not rule out a gout or infection. Typical sonographic findings of gout (double contour sign) can simulate findings of crystal deposits of calcium pyrophosphate. Pseudogout (Kalziumpyrophosphatdihydrat form of crystal-) BIOPHOTO ASSOCIATES / SCIENCE PHOTO LIBRARY var model = {thumbnailUrl ‘/-/media/manual/professional/images/pseudogout_high_de.jpg?la=de&thn=0&mw=350’, imageUrl: ‘/ – / media /manual/professional/images/pseudogout_high_de.jpg?la=de&thn=0 ‘, title:’ pseudogout (Kalziumpyrophosphatdihydrat-form of crystal) “, description: ‘ u003Ca id = ” v37892809 “”class = “” anchor “” u003e u003c / a u003e u003cdiv class = “”para “” u003e u003cp u003eEine calcium pyrophosphate deposition is visible as ill-defined and different density radiation transmittance (red arrows) inside the elbow joint. u003c / p u003e u003c / div u003e ‘credits’ BIOPHOTO ASSOCIATES / SCIENCE PHOTO LIBRARY’

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