Isaacs syndrome causes neuromuscular manifestations including myokymia.
(See also summary of disorders of the peripheral nervous system)
Isaacs syndrome causes neuromuscular manifestations including myokymia. (See also summary of disorders of the peripheral nervous system) The Isaacs syndrome (neuromyotonia) is a peripheral Übererregbarkeitssyndrom and i. Gen. regarded as a voltage-dependent potassium Kanalopathie, sometimes it occurs as a paraneoplastic syndrome. It can also occur concomitantly with other diseases (eg. As myasthenia gravis, thymoma, Hashimoto’s thyroiditis, vitamin B12 deficiency, celiac disease, connective tissue diseases) or inherited. Cause of Isaacs syndrome is not known. It is believed that the anomalies that have their origin in a peripheral nervous because they are canceled by curare, but persist usually under general anesthesia. The limbs are most often affected. The essential accompanying symptom is Myokymien-continuous “muscle waves”, which is reminiscent of a “bag of worms”. More are being added as Faszikulationssymptome Karpopedalspasmen, intermittent convulsions, increased sweating and Pseudomyotonia (impaired muscle relaxation after a strong contraction, but without the typical rising and falling electromyography [EMG] anomalies of true myotonia). Diagnosis Clinical findings of nerve conduction and EMG studies Diagnosis of Isaacs syndrome is based on the above clinical findings and the results of Nervenleitung- and EMG studies that show characteristic abnormalities; these anomalies include “anal discharges” in studies on nerve conduction and needle EMG studies fasciculation potentials myokymische discharges neuromyotonische discharges fibrillation potentials and seizure discharges, most clearly in the distal leg muscles. Laboratory tests should test for the striationalen, voltage-dependent calcium channel, for gliadin, glutamic acid decarboxylase (GAD), muscle acetylcholine receptor (AChR) and voltage-gated potassium channel antibodies. include. Therapy medications for symptom relief plasma exchange or iv immunoglobulin (IVIG) The drugs that alleviate the symptoms of Isaac’s syndrome include carbamazepine, phenytoin, gabapentin, mexiletine (experience is limited), valproate, lamotrigine and clonazepam. And plasma exchange, to a lesser extent, IVIG are generally advantageous and often are used in conjunction with prednisone and azathioprine.