Interstitial Lung Disease

(Diffuse parenchymal lung disease)

Among the many possible causes most connective tissue diseases and work-related inhalation exposures as well as many medications include (see Table. Causes of interstitial lung disease Some interstitial lung disease of unknown etiology have a characteristic histology, clinical appearance or manifestation and are therefore considered as independent diseases

Under interstitial pulmonary diseases refers to a heterogeneous group of diseases that are characterized by thickening of alveolar septa, proliferation of fibroblasts, collagen deposition and unimpeded progress of the disease lung fibrosis. Interstitial lung diseases can be classified (secondary to systemic diseases versus nichtgranulomatös, known cause versus unknown cause, primary lung disease versus z. B. acute versus chronic granulomatous) according to various criteria. Among the many possible causes most connective tissue diseases and work-related inhalation exposures as well as many medications include (see Table. Causes of interstitial lung disease Some interstitial lung disease of unknown etiology have a characteristic histology, clinical appearance or manifestation and are therefore considered as independent diseases Eosinophilic lung diseases pulmonary Langerhans cell histiocytosis (granulocytosis) lymphangioleiomyomatosis, pulmonary alveolar proteinosis sarcoidosis in up to 30% of patients with interstitial lung disease with no clear cause can be distinguished diseases primarily by characteristic histopathological features; these diseases as idiopathic interstitial pneumonia, respectively. Causes of interstitial lung disease category Examples connective tissue disease Ankylosing spondylitis (rare) Behcet’s syndrome (very rare) dermatomyositis and polymyositis Goodpasture’s syndrome IgG 4 related disease Mixed connective tissue disease RA Sjögren’s syndrome SLE Systemic sclerosis undifferentiated connective tissue disease Drug therapy Selected List: Amphotericin B , bleomycin, busulfan, carbamazepine, chlorambucil, cocaine, cyclophosphamide, diphenylhydantoin, flecainide, heroin, melphalan, methadone, Me thotrexat, methylphenidate, methysergide, mineral oil (via chronic microaspiration), nitrofurantoin, nitrosureas, procarbazine, silicone (sc injection), tocainide, vinca alkaloids (mitomycin) labor and environmental loads Inorganic (selection): aluminosis (caused by the action of metallic aluminum powder), asbestosis, “Baritosis”, berylliosis, coal worker’s pneumoconiosis, contact with hard metals (eg. B. cadmium, cobalt, titanium, tungsten, vanadium carbide), radiation fibrosis, siderosis, silicosis, stannosis, “talc pneumoconiosis” Organic (selection): Bagassose, Aviculturists lung, coffee workers lung, farmer’s lung, “Whirlpool lung”, “humidifier lung” , Malzarbeiterlunge, “maple bark stripper’s lung” mushroom workers lung infections Teearbeiterlunge aspergillosis histoplasmosis Parasitic infection mycobacteriosis Viral infection vasculitis eosinophils granulomatosis with polyangiitis giant (rare) granulomatosis microscopic polyangiitis with polyarteritis polyarteritis nodosa (rare) Takayasu’s arteritis Idiopathic interstitial pneumonia Acute interstitial pneumonia (crypto genes organizing pneumonia) Desquamative interstitial pneumonia Idiopathic pleuroparenchymale fibroelastosis idiopathic pulmonary fibrosis Lymphocytic interstitial pneumonia Non-specific interstitial pneumonia Respiratory bronchiolitis interstitial lung disease Various diseases amyloidosis Chronic aspiration Eosinophilic pneumonia Gaucher disease (rare) lipids pneumonia lymphangioleiomyomatosis microlithiasis neurofibromatosis Niemann Pick’s disease (rare) Pulmonary alveolar proteinosis Pulmonary Langerhans cell histiocytosis (granulomatosis) Pulmonary sarcoidosis lymphoma tuberous sclerosis

Health Life Media Team

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