promoting foods, delay or reduce the absorption of a drug and prevent the absorption of many antibiotics. You can alter the metabolism of drugs. Thus, stimulating. B. accelerate protein diets cytochrome P-450 and the metabolism of certain drugs. The consumption of grapefruit can inhibit cytochrome P-450-34A and slow down the metabolism of some drugs (eg. As amiodarone, carbamazepine, cyclosporine, certain calcium channel blockers). Diets that alter the bacterial flora can significantly affect the metabolism of certain drugs.
Diet can affect the body’s response to drug actives, conversely medicament active ingredients act on the food intake of. promoting foods, delay or reduce the absorption of a drug and prevent the absorption of many antibiotics. You can alter the metabolism of drugs. Thus, stimulating. B. accelerate protein diets cytochrome P-450 and the metabolism of certain drugs. The consumption of grapefruit can inhibit cytochrome P-450-34A and slow down the metabolism of some drugs (eg. As amiodarone, carbamazepine, cyclosporine, certain calcium channel blockers). Diets that alter the bacterial flora can significantly affect the metabolism of certain drugs. Some foods affect the body’s response to drug agents. For example, tyramine, trigger an ingredient of cheese with strong vasoconstrictor effect, a high-pressure crisis in patients taking MAO inhibitors while eating cheese. Nutrient deficiency may influence the absorption and metabolism of a drug. Heavy energy and protein deficiencies reduce the enzyme concentration in the tissue and interfere with the body’s response to pharmaceutical agents because they interfere with the absorption or protein binding and interfere with liver function. Changes in the gastrointestinal tract to inhibit the absorption of an active substance and vary the response to a drug. A lack of calcium, magnesium or zinc may affect the metabolism of drugs. Vitamin C deficiency decreases the activity of enzymes of drug metabolism, especially in the elderly. Many pharmaceutical drugs affect appetite, food absorption and tissue metabolism (see table: the effects of certain drugs on appetite, food intake and metabolism). Metoclopramide increases the gastrointestinal motility and decreased nutrient absorption. Opioids and anticholinergics weaken the motility of the gastrointestinal tract. Some drugs are better tolerated when taken with food. Effects of certain drugs on appetite, food intake and metabolism effect drug increases appetite alcohol, antihistamines, corticosteroids, dronabinol, insulin, megestrol acetate, mirtazapine, many psychotropic drugs, sulfonylureas, thyroid hormone decreases appetite antibiotics, bulk agent (methyl cellulose, guar gum), cyclophosphamide, digoxin , glucagon, indomethacin, morphine, fluoxetine reduces fat absorption orlistat Increases blood sugar levels octreotide, opioids, phenothiazines, phenytoin, probenecid, thiazide diuretics, corticosteroids, Warfarin decreases blood glucose levels ACE inhibitor, aspirin, barbiturates, beta-blockers, insulin, monoamine oxidase inhibitors (MAOIs), oral antihyperglycemics, phenacetin, phenylbutazone, sulfonamides reduced blood lipid levels aspirin and p-aminosalicylic acid, l-asparaginase, chlortetracycline, colchicine, dextrans, glucagon, niacin, phenindione, statins, sulfinpyrazone, trifluperidol Increases blood lipids Nebennierenkortikosteroide, chlorpromazine, ethanol, growth hormone, oral contraceptives (estrogen-progestogen type), thiouracil, Vitamin D Reduces protein metabolism chloramphenicol, tetracycline Individual active substances change mineral metabolism (see table: Possible effects of drugs on mineral metabolism). Certain antibiotics (eg. As Tetracycline) reduce iron absorption as well as certain foods (such. As vegetables, tea, bran). Possible effects of drugs on mineral metabolism drugs Follow diuretics, especially thiazides, and corticosteroids can deplete the body of potassium * laxatives when used repeatedly Can potassium exhaust * cortisol, aldosterone and deoxycorticosterone Causes pronounced sodium and water retention, at least temporarily sulfonyl ureas and lithium prevent the uptake or release of iodine by the thyroid gland. Oral contraceptives Lower the blood zinc levels and increase the copper mirror. Certain antibiotics (such as Tetracycline) can reduce iron absorption * depletion of potassium increases susceptibility to digoxin induced cardiac arrhythmias. sodium and water retention is much less pronounced with prednisone, prednisolone and other Corticosteroidanaloga. Certain drugs affect the absorption or metabolism of vitamin (see Table: Possible effects of drugs on the absorption or metabolism of vitamins.). Possible effects of drugs on the absorption or metabolism of vitamins. Drug effects Ethanol Impairs Thiaminnutzung isoniazid Does the niacin and Pyridoxinstoffwechsel ethanol and oral contraceptives inhibit folic acid absorption phenytoin, phenobarbital, primidone, or phenothiazine Causes in most patients folic acid deficiency * probably because the hepatic microsomal enzymes that metabolize the Mdikamente are affected. Anticonvulsants Can a vitamin D deficiency cause aminosalicylic, slow-release potassium iodide, colchicine, trifluoperazine, metformin, ethanol and oral contraceptives. Can taking vitamin B12 Oral contraceptives interfere with high progesterone content. , Probable cause may be due to a metabolically induced tryptophan deficiency depression. Proton pump inhibitors may cause deficiencies of vitamin B12, vitamin C, iron, calcium and magnesium * folic acid-containing supplements may reduce the effect of phenytoin.