Infectious Mononucleosis

Infectious mononucleosis caused by the Epstein-Barr virus (EBV, human herpes virus type 4) and is characterized by fatigue, fever, pharyngitis, and lymphadenopathy. The fatigue can persist for weeks or months. Occasionally, severe complications, incl. Airway obstruction, splenic rupture and neurological syndromes occur. The diagnosis is clinically placed or EBV with serological tests. Treatment is supportive.

EBV is a herpes virus that infects 50% of children before age 5. About 90% of adults are seropositive in terms of EBV Man is the reservoir.

Infectious mononucleosis caused by the Epstein-Barr virus (EBV, human herpes virus type 4) and is characterized by fatigue, fever, pharyngitis, and lymphadenopathy. The fatigue can persist for weeks or months. Occasionally, severe complications, incl. Airway obstruction, splenic rupture and neurological syndromes occur. The diagnosis is clinically placed or EBV with serological tests. Treatment is supportive. EBV is a herpes virus that infects 50% of children before age 5. About 90% of all adults are Man is the reservoir seropositive with respect to EBV. EBV infection is usually asymptomatic. Pathophysiology After the first replication in the nasopharynx, the virus infects B cells. It develop morphologically abnormal (atypical) lymphocytes, mainly from CD8 + T cells that respond to the infection. After the primary infection, EBV persists lifelong in its human host, particularly in B lymphocytes, and is intermittently excreted asymptomatic from the oropharynx. The virus can be found in 15-25% of oropharyngeal secretions of healthy EBV-positive adults. In immunocompromised patients (eg. As organ transplant recipients, HIV-infected individuals), there is a frequent and increased excretion. EBV has not been isolated from environmental samples and is not very contagious. Transfer to a transmission can occur through a transfusion of blood products, but more often is a transmission via kissing between an uninfected and an EBV seropositive person who, by the virus asymptomatic. Only about 5% of patients acquire the virus from an acutely ill person. A transfer in the early years is more common in persons with lower socioeconomic status and in cramped, crowded conditions statt.Assoziierte disease EBV is statistically associated with and probably causally involved in Burkitt’s lymphoma, certain B-cell tumors in patients with weakened immune systems nasopharyngeal carcinoma EBV is no cause of chronic fatigue syndrome ( “chronic fatigue syndrome”). However, a syndrome characterized by fever, interstitial pneumonitis, pancytopenia, and uveitis cause (d. e. chronic active EBV infection). Symptoms and complaints For most small children runs the primary EBV infection asymptomatic. The symptoms of infectious mononucleosis often develop in older children and adults. The incubation period is about 30-50 days. The fatigue can last for months, usually with a maximum during the first 2-3 weeks. Most patients have the triad of fever pharyngitis adenopathy The fever usually rises in the afternoon or early evening to a maximum, with temperatures around 39.5 ° C, but it can reach 40.5 ° C. The pharyngitis may be difficult, painful, and exudative and remember a streptococcal pharyngitis. Infectious mononucleosis (pharyngitis) DR P. MARAZZI / SCIENCE PHOTO LIBRARY var model = {thumbnailUrl ‘/-/media/manual/professional/images/m1650140-infectious-mononucleosis-pharyngitis-science-photo-library-high_de.jpg?la = en & thn = 0 & mw = 350 ‘, imageUrl:’ /-/media/manual/professional/images/m1650140-infectious-mononucleosis-pharyngitis-science-photo-library-high_de.jpg?la=de&thn=0 ‘, title:’ infectious mononucleosis (pharyngitis) ‘description:’ u003Ca id = “v38396533 ” class = “”anchor “” u003e u003c / a u003e u003cdiv class = “”para “” u003e u003cp u003eDieses Photo is swollen and purulent tonsils in a patient with infectious mononucleosis u003c / p u003e u003c / div u003e ‘credits’. DR P. MARAZZI / SCIENCE PHOTO LIBRARY’

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