Infections Caused By Adenovirus

Infections caused by one of the many adenoviruses can be asymptomatic or cause specific syndromes, incl. Slight respiratory infections, keratoconjunctivitis, gastroenteritis, cystitis and primary pneumonia. The diagnosis is made clinically. Treatment is supportive.

Adenoviruses are DNA viruses that after 3 important Kapsidantigenen (hexon, penton and fiber) are divided. Adenoviruses are often through contact with secretions (incl. Those on fingers of an infected person) transferred from an infected person or by contact with a contaminated object (eg. As towel, instrument). Infections can also be airborne or transmitted by water (eg. As in swimming). Asymptomatic respiratory or gastrointestinal virus excretion may continue for months or even years.

Infections caused by one of the many adenoviruses can be asymptomatic or cause specific syndromes, incl. Slight respiratory infections, keratoconjunctivitis, gastroenteritis, cystitis and primary pneumonia. The diagnosis is made clinically. Treatment is supportive. Adenoviruses are DNA viruses that after 3 important Kapsidantigenen (hexon, penton and fiber) are divided. Adenoviruses are often through contact with secretions (incl. Those on fingers of an infected person) transferred from an infected person or by contact with a contaminated object (eg. As towel, instrument). Infections can also be airborne or transmitted by water (eg. As in swimming). Asymptomatic respiratory or gastrointestinal virus excretion may continue for months or even years. Symptoms and complaints in immunocompetent hosts, most Adenovireninfektionen asymptomatic. In symptomatic infections a broad spectrum of clinical manifestations is possible. The most common disease, especially in children, including fever, which tends to be> 39 ° C and> 5 days continues. Sore throat, cough, rhinorrhea or other respiratory symptoms may occur. A separate syndrome include conjunctivitis, pharyngitis and fever (pharyngokonjunktivales fever). Rare adenoviral syndromes in children include severe bronchiolitis (bronchiolitis) and pneumonia. In closed communities of young adults (. Eg military recruits) can cause outbreaks of respiratory diseases; the symptoms include fever and symptoms of lower respiratory tract, usually tracheobronchitis, and occasionally pneumonia. An epidemic keratoconjunctivitis (etiology) runs sometimes difficult and occurs both sporadically and in epidemic form. The conjunctivitis is often on both sides. It can develop a preauricular adenopathy. There may be more that can be made visible with the fluorescein staining a chemosis, pain and punctual Kornealäsionen. Systemic symptoms or complaints are weak or completely absent. An epidemic keratoconjunctivitis usually heals from within 3-4 weeks, although corneal lesions may persist much longer. Nonrespiratory adenoviral syndromes include hemorrhagic cystitis, infant diarrhea and encephalitis. Most patients recover completely. Even a severe adenoviral pneumonia runs, rare fulminant cases primarily in infants, military recruits and immunosuppressed patients apart, not fatal. Diagnosis Clinical assessment Laboratory diagnosis of adenovirus infection has rarely affect the treatment. During an acute disease the virus from respiratory and eye secretions, as well as frequently from the stool and urine can be isolated. A four-fold increase in serum antibody titer is an indication of a recent infection. Therapy Symptomatic Treatment Treatment is symptomatic and supportive. In immunocompromised patients ribavirin and cidofovir have been used; the results vary. To minimize the risk of transmission, medical personnel should be after the examination of infected patients change gloves and perform a hygienic hand disinfection, sterilize instruments properly and not using ophthalmic instruments common to several patients. Prevention vaccines containing live adenoviruses types 4 and 7 contained and were administered orally in the form of an enteric capsule led to a reduction of diseases of the lower respiratory tract. The vaccine has not been available for several years, but was reintroduced in the 2011th It is available only for military personnel, however. It can be given to patients aged 17 and 50 years and should not be to women who are pregnant or breastfeeding are administered.

Health Life Media Team

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