Infant Botulism

Neugeborenenbotulismus caused by the ingestion of Clostridium botulinum spores, which colonize the colon and form toxin in vivo.

A Neugeborenenbotulismus usually occurs in infants <6 months ago. The youngest patient was documented 2 weeks and the oldest was 12 months of age. Unlike food-related botulism Neugeborenenbotulismus is not caused by ingestion of preformed toxin. Most cases are idiopathic, although some on the intake of honey, the C. botulinum - are to trace contained spores. Infants <12 months, therefore, should not be fed with honey.

Neugeborenenbotulismus caused by the ingestion of Clostridium botulinum spores, which colonize the colon and form toxin in vivo. A Neugeborenenbotulismus usually occurs in infants <6 months ago. The youngest patient was documented 2 weeks and the oldest was 12 months of age. Unlike food-related botulism Neugeborenenbotulismus is not caused by ingestion of preformed toxin. Most cases are idiopathic, although some on the intake of honey, the C. botulinum - are to trace contained spores. Infants <12 months, therefore, should not be fed with honey. Most cases involve type A or B toxin. Symptoms and complaints to constipation occurs initially in 90% of cases, followed by neuromuscular paralysis, beginning with the cranial nerves and proceeding to peripheral and respiratory muscles. It is characteristically to cranial nerve palsies such. As ptosis, paralysis extraocular muscles, weak crying, poor feeding, reduced gag reflex, accumulation of oral secretions, weak muscle tone ( "floppy baby syndrome") and an expressionless face. The severity varies from a mild lethargy and delayed food intake up to severe hypotension and respiratory insufficiency. Diagnostic stool tests First Botulism should be suspected based on clinical criteria. Therapy should not be up to confirm serviced by the outstanding test results. Neugeborenenbotulismus can be confused with sepsis, congenital muscular dystrophy, spinal muscular atrophy, hypothyroidism and benign congenital hypotonia. The detection of C. botulinum toxin in the stool confirms the clinical diagnosis. Therapy Human botulism immunoglobulins infants are hospitalized, and a supportive treatment is performed as required. Since pathogens and toxins are excreted in the stool for weeks to months after the onset of symptoms, proper precautions must be followed. Special treatment of botulism with human botulism immune globulin that the "Botulism Treatment and Prevention Program (IBTPP- [510] 231-7600" can be purchased, see also the IBTPP site). This antidote is obtained from pooled human donors which have high titers of antibodies to A and / or B toxin. The treatment once the diagnosis is suspected to wait for confirmatory test results, which can take days, is dangerous is to take place. The dose is 75 mg / kg i.v. 1 time, slowly administered. The Heptavalent antitoxin made from horse serum used in adults, is not recommended for infants. Antibiotics are not given because they can lyse in the gut C. botulinum toxin and increase availability.

Health Life Media Team

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