Increased High-Density Lipoprotein Levels (Hdl)

Increased high-density lipoprotein (HDL) levels are at a HDL-cholesterol> 80 mg / dL (> 2.1 mmol / l).

Elevated HDL levels correlate generally with a lower cardiovascular risk; High HDL levels, as found in some primary genetic disorders, may not protect against cardiovascular risk, as they are likely to occur along with other Lipidstoffwechsel- and metabolic disorders.

Increased high-density lipoprotein (HDL) levels are at a HDL-cholesterol> 80 mg / dL (> 2.1 mmol / l). Elevated HDL levels correlate generally with a lower cardiovascular risk; High HDL levels, as found in some primary genetic disorders, may not protect against cardiovascular risk, as they are likely to occur along with other Lipidstoffwechsel- and metabolic disorders. Primary causes of elevated HDL levels are single or multiple genetic disorders that manifest themselves by an overproduction or reduced degradation of HDL. Secondary causes of high HDL levels include chronic alcoholism without cirrhosis Primary biliary cirrhosis hyperthyroidism drugs (eg, corticosteroids, insulin, phenytoin.) Negative test results to make a primary cause probably. The unexpected occurrence of a high HDL in patients who do not receive lipid lowering medication should have a diagnostic evaluation with regard to secondary causes the measurement of AST, ALT and TSH result. Cholesteryl () deficiency is a rare autosomal recessive disorder that is caused by a mutation of the CETP gene. CETP facilitates the transfer of Cholesterinestern of HDL to other lipoproteins and CETP deficiency results in LDL levels low cholesterol and HDL slower degradation. Affected patients show no symptoms, but have HDL levels> 150 mg / dl (> 3.9 mmol / l). A protective in terms of cardiovascular disease has not been demonstrated so far. A treatment is not required. Familial hyperalphalipoproteinemia is an autosomal dominant disorder caused the produce by a variety of known and unknown genetic mutations, incl. Those that apolipoprotein A-I overproduction and apolipoprotein C-III variants. The disorder is usually discovered by accident, when the plasma levels of HDL are> 80 mg / dl. Affected patients have no other symptoms or clinical evidence. Treatment is not necessary.

Health Life Media Team

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