Hiv-Associated Nephropathy

HIV-associated nephropathy is similar clinical findings which the focal, segmental glomerulosclerosis and often biopsy hallmarks of a “collapsing” glomerulopathy (a variant of focal segmental glomerulosclerosis) characterized.

HIV-associated nephropathy (HIVAN), a type of nephrotic syndrome appears to be more common among dark-skinned patients with HIV who use drugs by injection or with poor compliance with antiretroviral therapy. The infection of kidney cells with HIV can contribute to the deterioration.

HIV-associated nephropathy is similar clinical findings which the focal, segmental glomerulosclerosis and often biopsy hallmarks of a “collapsing” glomerulopathy (a variant of focal segmental glomerulosclerosis) characterized. HIV-associated nephropathy (HIVAN), a type of nephrotic syndrome appears to be more common among dark-skinned patients with HIV who use drugs by injection or with poor compliance with antiretroviral therapy. The infection of kidney cells with HIV can contribute to the deterioration. Most clinical results are similar to those of focal segmental glomerulosclerosis, but hypertension is less common and increases remain the kidneys. Most patients with HIVAN experience a rapid progression to ESRD within 1-4 months. Diagnostic kidney biopsy HIVAN is used in patients with nephrotic syndrome or nephropathy who have AIDS or AIDS-related symptoms, suspected. A HIVAN should be distinguished from the many other disorders that occur in HIV-infected patients with a higher frequency and can cause other renal diseases, such as thrombotic microangiopathy (hemolytic uremic syndrome and thrombotic thrombocytopenic purpura), immune complex-mediated glomerulonephritis, drug-induced interstitial nephritis (due to indinavir and ritonavir) and rhabdomyolysis (due to statins). If an ultrasound is performed, this shows that the kidneys are enlarged and highly echogenic. Normally, a kidney biopsy is performed. The light microscopy shows a Kapillarkollaps varying severity (collapsing glomerulopathy) and an increase of mesangial matrix different proportions. The tubular cells show marked degenerative changes and a tubular atrophy or microcytic extension. Often interstitial Immunzellinfiltrate, fibrosis and edema. Tubular reticular inclusions, similar to those in SLE are found in the endothelial cells, because of the effective HIV therapy but now rare. Normal blood pressure and persistent enlarged kidneys help to distinguish between HIVAN and focal segmental glomerulosclerosis. HIV-associated nephropathy ( “Collapsing” glomerulopathy) Figure provided by Agnes Fogo, M.D., and the American Journal of Kidney Disease, Atlas of Renal Pathology (see www.ajkd.org). var model = {thumbnailUrl: ‘/-/media/manual/professional/images/hiv-associated_nephropathy_collapsing_glomerulopathy_high_de.jpg?la=de&thn=0&mw=350’ imageUrl: ‘/ – / media / manual / professional / images / hiv associated_nephropathy_collapsing_glomerulopathy_high_de ? .jpg lang = en & thn = 0 ‘, title:’ HIV-associated nephropathy ( “Collapsing ” glomerulopathy) ‘description:’ u003Ca id = “”v38396929 “” class = “”anchor “” u003e u003c / a u003e u003cdiv class = “”para “” u003e u003cp u003eFokal-segmental glomerulosclerosis

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