Histoplasmosis

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Histoplasmosis is a pulmonary disease and hematogenous, which is caused by Histoplasma capsulatum. They often becomes chronic and is usually followed by an asymptomatic primary infection. The symptoms are those of pneumonia or nonspecific chronic disease. The diagnosis made by detection of the pathogen in sputum or tissue, or the use of a specific serum and urine antigen. The therapy, if necessary, is carried out with amphotericin B or an azole.

(See also the “Infectious Diseases Society of America Practice Guidelines for the Management of Patients with histoplasmosis.”)

Histoplasmosis is a pulmonary disease and hematogenous, which is caused by Histoplasma capsulatum. They often becomes chronic and is usually followed by an asymptomatic primary infection. The symptoms are those of pneumonia or nonspecific chronic disease. The diagnosis made by detection of the pathogen in sputum or tissue, or the use of a specific serum and urine antigen. The therapy, if necessary, is carried out with amphotericin B or an azole. (See also the “Infectious Diseases Society of America Practice Guidelines for the Management of Patients with histoplasmosis.”) Histoplasmosis occurs worldwide. In the US, the endemic area for histoplasmosis includes the river valleys of the Ohio and Mississippi, which expand to parts of northern Maryland, southern Pennsylvania, central New York and Texas down. And there were also found small herd in other states like Florida and along the rivers St. Lawrence and Rio Grande. H. capsulatum growing in nature or in culture at room temperature in the mold form, but is converted at 37 ° C and in tissue invasion into small (1 to 5 microns in diameter) to the yeast cells. Infection occurs by inhalation of conidia (spores caused by micellar fungi) from soil or dust into being that have been contaminated by droppings from birds or bats. A serious illness is more common after an intense, prolonged exposure and in men, small children or people in front with impaired T-cell mediated immunity. The initial infection is in the lungs instead and usually remains limited to this, but can also hematogenous other organs scatter when the cell-mediated immune functions of the host are compromised. A progressive disseminated histoplasmosis is one of the AIDS-defining infections. Symptoms and signs Most Histoplasmainfektionen asymptomatic or so light that patients do not seek medical attention. The disease occurs in three main forms: Acute primary histoplasmosis is a syndrome characterized by fever, cough, myalgia, chest pain and malaise with variable severity. Sometimes an acute pneumonia developed (information can be found on physical examination and chest x-ray). A chronic cavernous histoplasmosis is characterized by pulmonary lesions that are often atypical and remember a cavernous tuberculosis. It manifests itself with a worsening cough and dyspnea and proceeds ultimately on to a pronounced respiratory dysfunction. A dissemination does not occur. A progressive disseminated histoplasmosis characteristically comprises a generalized involvement of the reticuloendothelial system with hepatosplenomegaly, lymphadenopathy, bone marrow involvement and occasionally oral or gastrointestinal ulcerations. The course is usually subacute or chronic, with only non-specific, often discrete symptoms (eg. As fever, fatigue, weight loss, weakness, malaise). The state of HIV-positive patients may deteriorate inexplicably. There may be an interest of cerebrospinal fluid, causing meningitis or focal lesions in the brain. An infection of the adrenal glands is rare, but can lead to Addison’s disease. A severe pneumonia is rare, but patients with AIDS may develop severe acute pneumonia with hypoxia, which resembles a Pneumocystis infection jirovecii-, and hypotension, changes in mental status, coagulopathy or rhabdomyolysis. Histoplasmosis Image courtesy of Susan Lindsley on Public Health Image Library of the Centers for Disease Control and Prevention. var model = {thumbnailUrl: ‘/-/media/manual/professional/images/histoplasmosis_orig_de.jpg?la=de&thn=0&mw=350’ imageUrl: ‘/-/media/manual/professional/images/histoplasmosis_orig_de.jpg?la = en & thn = 0 ‘, title:’ histoplasmosis ‘description:’ u003Ca id = “v38396412 ” class = “”anchor “” u003e u003c / a u003e u003cdiv class = “”para “” u003e u003cp u003eBei immunosuppressed patients can histoplasmosis spread to the skin

Health Life Media Team

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