For more information, s. Hepatitis A Vaccine ACIP Recommendations. Preparations hepatitis A vaccines (HepA) are prepared from formalin-inactivated derived from cell cultures hepatitis A virus. There are two hepatitis A vaccines; both available as substances for children and adults. A vaccine of the hepatitis A and hepatitis B vaccine combined (Twinrix®) is also available. Indications HepA vaccination is a routine childhood vaccination (see Table: Recommended vaccination schedule for the age of 0-6 years). The HepA vaccine is indicated if the following conditions exist: desire for protection against hepatitis A in people who have not been vaccinated traveling or working in endemic areas exposedness at work (eg working with primates infected with hepatitis. a virus [HAV] are infected, or HAV in a research laboratory) sex between men illegal drug use (injected or not) such as methamphetamine treatment with clotting factor concentrates chronic liver disease Expected close personal contact (z. B. as household members or regular Babysitter) with an adopted child during the first 60 days after the child’s arrival in the US from an endemic area combined HEPA and HepB vaccine can be used in individuals ? 18 years, the indications for ent have either the hepatitis A or the hepatitis B vaccine and which have not been previously vaccinated with a component of the vaccine. Contraindications and precautions The main contraindication is a severe allergic reaction (eg., Anaphylaxis) after a previous dose or to a vaccine component The most important precaution is Moderate or severe illness with or without fever (vaccination, if possible postponed until the disease is over) dosage and administration The dose is 0.5 ml in the until the age of 18 years or 1 ml i.m. for adults (age ? 19 years). Children a series of two doses is usually given at age 12 to 23 months and 6 to 18 months after the first dose. Adults, the vaccine is given in a series of 2 doses: at 0 months and at 6 to 18 months. Adults can also be the combined HEPA and HepB vaccine given with a 3-dose schedule: at 0, 1 and 6 months. The first and the second dose should be ? 4 weeks apart and the 2nd and 3rd dose should be ? 5 months apart. Alternatively, the vaccine can be administered on a 4-dose schedule: on days 0, 7 and 21 to 30, followed by a booster 12 months after the first dose. Once the adoption of a child is planned from an endemic area, close contacts should be the first dose of the two-dose vaccine series HepA be given, ideally ? 2 weeks before the adopted child arrives. Undesirable effects serious side effects have been reported. Weak side effects include pain, erythema, swelling and occasionally induration at the injection site.