Hemoglobin-S- ?-Thalassemia

Hemoglobin S-?-thalassemia is one of the hemoglobinopathies (hemoglobinopathies) and leads to symptoms of sickle cell disease are similar, but less pronounced with those.

Because of the increased frequency of hemoglobin-S- as well as ?-thalassemia genes in the same population group, the inheritance of both defects is relatively common. Clinically, the disease leads to symptoms of moderate anemia with signs of sickle cell disease, but occur less frequently and are less difficult than in sickle cell anemia. In the stained blood smears there is a mild to moderate microcytic anemia together with a few sickle cells. For the diagnosis, a quantitative hemoglobin investigation is required. The hemoglobin A2 content is> 3%. In electrophoresis hemoglobin S there before, and hemoglobin A may be reduced or absent. The degree of increase of hemoglobin F varies. If treatment is necessary, the measures which in sickle cell disease are similar.

Hemoglobin S-?-thalassemia is one of the hemoglobinopathies (hemoglobinopathies) and leads to symptoms of sickle cell disease are similar, but less pronounced with those. Because of the increased frequency of hemoglobin-S- as well as ?-thalassemia genes in the same population group, the inheritance of both defects is relatively common. Clinically, the disease leads to symptoms of moderate anemia with signs of sickle cell disease, but occur less frequently and are less difficult than in sickle cell anemia. In the stained blood smears there is a mild to moderate microcytic anemia together with a few sickle cells. For the diagnosis, a quantitative hemoglobin investigation is required. The hemoglobin A2 content is> 3%. In electrophoresis hemoglobin S there before, and hemoglobin A may be reduced or absent. The degree of increase of hemoglobin F varies. If treatment is necessary, the measures which in sickle cell disease are similar.

Health Life Media Team

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