Hemoglobin E Disease

The homozygous hemoglobin E disease (a hemoglobinopathy; hemoglobinopathies) causes a mild hemolytic anemia, usually without splenomegaly.

Hemoglobin E is the world’s third most common (after hemoglobin A and hemoglobin S) hemoglobin variant. It comes mainly in the dark-skinned people and in Southeast Asia (> 15% homozygotes) in the Chinese population, it is rarely seen. Heterozygous (hemoglobin AE) are asymptomatic. Patients with heterozygous hemoglobin E and ?-thalassemia have a more severe hemolytic anemia than the S-thalassemia or homozygous hemoglobin E disease and beyond usually splenomegaly.

The homozygous hemoglobin E disease (a hemoglobinopathy; hemoglobinopathies) causes a mild hemolytic anemia, usually without splenomegaly. Hemoglobin E is the world’s third most common (after hemoglobin A and hemoglobin S) hemoglobin variant. It comes mainly in the dark-skinned people and in Southeast Asia (> 15% homozygotes) in the Chinese population, it is rarely seen. Heterozygous (hemoglobin AE) are asymptomatic. Patients with heterozygous hemoglobin E and ?-thalassemia have a more severe hemolytic anemia than the S-thalassemia or homozygous hemoglobin E disease and beyond usually splenomegaly. In heterozygotes (hemoglobin AE), the routine laboratory studies of peripheral blood are unremarkable. In homozygotes, a slight microcytic anemia shows with clear target cells. The diagnosis of hemoglobin E disease is provided by hemoglobin electrophoresis. The treatment in homozygous patients with severe disease involves regular transfusions generally.

Health Life Media Team

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