Hemoglobin C Disease

Hemoglobin C disease is one of the hemoglobinopathies (hemoglobinopathies) and leads to symptoms of sickle cell disease are similar, but less pronounced with those.

This genetic trait is found in about 2-3% of dark-skinned US population, but most sufferers are asymptomatic. The symptoms are similar to their homozygous sickle cell disease which, although they are weaker in severity. Abdominal discomfort such as in sickle cell disease do not occur. The spleen is usually enlarged, and there may be a splenic sequestration.

Hemoglobin C disease is one of the hemoglobinopathies (hemoglobinopathies) and leads to symptoms of sickle cell disease are similar, but less pronounced with those. This genetic trait is found in about 2-3% of dark-skinned US population, but most sufferers are asymptomatic. The symptoms are similar to their homozygous sickle cell disease which, although they are weaker in severity. Abdominal discomfort such as in sickle cell disease do not occur. The spleen is usually enlarged, and there may be a splenic sequestration. The suspicion of a hemoglobin C disease is present in all patients with a family history of this disease and in dark-skinned patients presenting with clinical symptoms of sickle cell disease, particularly adults with splenomegaly. The anemia is usually mild in intensity, but may be moderate to heavy. It is a normocytic anemia, red blood cells are found with intracytoplasmic crystals in the blood smear 30 to 100% target cells and spherocytes and in rare cases. Nucleated red blood cells may be present, but show no sickle cell erythrocytes phenomenon. In electrophoresis can be found hemoglobin type C In heterozygotes the only abnormality is the presence of target cells. Specific treatment is not recommended. Anemia is not as hard as a rule that blood transfusions are needed.

Health Life Media Team

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