Hashimoto’S Thyroiditis

(Autoimmune thyroiditis, chronic lymphocytic thyroiditis: Hashimoto’s thyroiditis)

Hashimoto’s thyroiditis is a chronic, autoimmune inflammation of the thyroid with lymphocytic infiltration. One finds (Editor’s note: Initial) a painless thyroid enlargement and the symptoms of hypothyroidism. For diagnosis, the detection of high levels of antibodies against thyroid peroxidase belongs. A lifelong l-Thyroxinsubstitution is usually required.

Hashimoto’s thyroiditis is a chronic, autoimmune inflammation of the thyroid with lymphocytic infiltration. One finds (Editor’s note: Initial) a painless thyroid enlargement and the symptoms of hypothyroidism. For diagnosis, the detection of high levels of antibodies against thyroid peroxidase belongs. A lifelong l-Thyroxinsubstitution is usually required.

(See illustration of the thyroid function.) Hashimoto’s disease is a chronic, autoimmune inflammation of the thyroid with lymphocytic infiltration. One finds (Editor’s note: Initial) a painless thyroid enlargement and the symptoms of hypothyroidism. For diagnosis, the detection of high levels of antibodies against thyroid peroxidase belongs. A lifelong l-Thyroxinsubstitution is usually required. Hashimoto’s thyroiditis is the most common cause of primary hypothyroidism in North America (Editor’s note: and in Europe). Prevalence is several times as high as among men with women. The incidence increases with age and in patients with chromosomal abnormalities such. B. to Down’s syndrome, Turner’s syndrome and Klinefelter’s syndrome. A family history of thyroid disease is common. Hashimoto’s thyroiditis as well as Graves’ disease is sometimes associated with other autoimmune diseases such. B. Addison’s disease (adrenal), diabetes mellitus type 1, hypoparathyroidism, vitiligo, premature graying of the hair, pernicious anemia, connective tissue diseases (e.g., as rheumatoid arthritis, SLE, Sjögren’s syndrome), celiac disease and the Schmidt syndrome (Addison’s disease , diabetes and hypothyroidism on the bottom of a Hashimoto’s thyroiditis). An accumulation of thyroid tumors may occur rarely are lymphoma of the thyroid. Histologically extensive lymphocytic infiltration with lymphoid follicles and scarring. Symptoms and discomfort patients experience (Editor’s note: initial) over a painless thyroid enlargement and a feeling of a lump in the throat. The study shows (Editor’s note: initial) usually a goiter rubbery consistency. Most patients show (Editor’s note: initial) symptoms of hyperthyroidism. Diagnostic thyroxine (T4) thyroid-stimulating hormone (TSH), thyroid autoantibodies The testing consists of the measurement of T4, TSH and thyroid autoantibodies. In the early stage of the disease the values ??of free T4 and TSH are normal; but high levels of antibodies against thyroid peroxidase and less frequently there are already found against thyroglobulin. The thyroid uptake of radioactive iodine may be increased, possibly due to poor organification of iodide and as this continues to remain in the thyroid. Later in patients develop hypothyroidism with decreased T4 and increased TSH. An investigation with regard to other autoimmune diseases is recommended only if it also is clinical evidence. Therapy Treatment is by substitution of thyroid hormones. Rarely hypothyroidism is only temporary, most patients require lifelong shield nozzle hormone replacement with L-thyroxine in a dose of 75-150 micrograms p.o. 1 times a day under the control of TSH levels. Conclusion Hashimoto’s thyroiditis is an autoimmune inflammation of the thyroid gland. Patients sometimes have other autoimmune diseases. T4 and TSH levels are normal at first, but later decreased T4 and TSH increases, and patients are clinically hypothyroid. but high levels of antibodies against thyroid peroxidase and less frequently there are already found against thyroglobulin. A lifelong thyroxine hormone replacement is usually required.

Health Life Media Team

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