The Related buttercups Canadian turmeric (Hydrastis canadensis) is an endangered plant in the US. Their active ingredients are Hydrastine and berberine, which have an antiseptic effect. Goldenseal is standardized in liquid, tablet and capsule form to the active components.
(See also nutritional supplements Overview.) The Related buttercups Canadian turmeric (Hydrastis canadensis) is an endangered plant in the US. Their active ingredients are Hydrastine and berberine, which have an antiseptic effect. Goldenseal is standardized in liquid, tablet and capsule form to the active components. When allegations mouth ulcers, eye infections and skin irritations are applied different preparations of Canadian turmeric as antiseptic rinse with vaginal infections as vaginal shower. In flu drugs combined with echinacea. Goldenseal is also used as a remedy for indigestion and diarrhea. Documents the effectiveness of goldenseal alone as cold remedies is not supported (1). In two relatively well hedged, but small studies diarrhea were under the influence of berberine by (from Canadian turmeric isolated active ingredient) (2-3). However, there are few, if any, more recent, large, randomized, blinded clinical studies on goldenseal extract. Side Effects Goldenseal can have numerous side effects, including nausea, anxiety, dyspepsia, uterine contractions, newborn jaundice or worsening of hypertension. High doses it can lead to seizures and respiratory failure and harm the heart muscle contractions. Pregnant and lactating women, newborns and patients with convulsive disorders or bleeding disorders should not take Canadian turmeric. A recent in vitro study of the active ingredients of goldenseal, berberine in particular, shows an increase in the risk of DNA damage, leading to oncogenic effects (4). Drug interactions Goldenseal can interact with Wafarin and berberine may reduce the Antikoagulanzienwirkung of heparin. In addition, a recent review of plant extracts that goldenseal, berberine in particular, is a weak inhibitor of CYP3A4 and CYP2D6 enzymes (5) is important in metabolism and in the elimination of many drugs. Notes goldenseal Rehman J, Dillow JM, Carter SM, et al. Increased production of antigen-specific immunoglobulins G and M Following in vivo treatment with the medicinal plants Echinacea angustifolia and Hydrastis canadensis. Immunol Lett 68 (2-3): 391-395, 1999. Khin-Maung-U, Myo-Khin, Nyunt-Nyunt-Wai, et al. Clinical trial of berberine in acute watery diarrhea. Br Med J (Clin Res Ed) 291 (6509): 1601-1605, 1995. Rabbani GH, Butler T, Knight J, et al. Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae. J Infect Dis 155 (5): 979-984, 1987. Chen S, Wan L, bed L, et al. Mechanism study of goldenseal-associated DNA damage. Toxicol Lett 221 (1): 64-72, 2013. Hermann R, Judge O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med 78 (13) 1458-1477, 2012th